Cerebral infarction in systemic lupus: association with anticardiolipin antibodies.
Cerebral infarction in systemic lupus: association with anticardiolipin antibodies.
复制标题
系统性狼疮脑梗塞：与抗心磷脂抗体相关。
DOI：
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发表时间：
1984
影响因子：
3.7
通讯作者：
G. R. Hughes
中科院分区：
文献类型：
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作者：
E. Harris;A. Gharavi;R. Asherson;Boey Ml;G. R. Hughes
我们报告了 15 名患者，其中 13 名患有系统性狼疮，两名患有“狼疮样”疾病并发展为脑梗塞的患者。使用新设计的固相放射免疫测定法显示，所有十五名患者的抗心磷脂抗体水平均升高。在所有接受测试的 11 名患者中均检测到了狼疮抗凝物。据认为，抗心磷脂抗体和狼疮抗凝物组成了能够引起脑血管损伤和血栓形成从而导致脑梗塞的抗磷脂抗体群体。这些抗体也可能在狼疮以外的自身免疫性疾病中发挥致病作用，其中脑血栓性疾病是狼疮的一个突出特征。
We report fifteen patients, thirteen with systemic lupus and two patients with a "lupus-like" illness who developed cerebral infarction. All fifteen patients were shown to have elevated anticardiolipin antibody levels using a newly devised solid phase radioimmunoassay. The lupus anticoagulant was detected in all eleven patients tested. It is proposed that anticardiolipin antibodies and the lupus anticoagulant make up a population of antiphospholipid antibodies capable of causing cerebral vascular injury and thrombosis resulting in cerebral infarction. These antibodies may also play a pathogenic role in autoimmune disorders other than lupus where cerebral thrombotic disease is a prominent feature.