Self-reported cognition and marijuana use in older adults: Results from the national epidemiologic survey on alcohol and related conditions-III
Self-reported cognition and marijuana use in older adults: Results from the national epidemiologic survey on alcohol and related conditions-III
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DOI：
10.1016/j.addbeh.2020.106437
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发表时间：
2020-09-01
影响因子：
4.4
通讯作者：
Sherman, Brian J.
中科院分区：
文献类型：
--
作者：
Benitez, Andreana;Lauzon, Steven;Sherman, Brian J.
老年人使用避孕药的情况前所未有地增加，但人们对其对这一人群认知能力的影响知之甚少，因为老年人的认知能力下降的风险很高。因此，我们调查了大麻的使用和使用特征是否与年龄>= 50岁的老年人自我报告的认知相关，使用酒精和相关条件的国家流行病学调查-III。受访者要么从未使用过大麻（“从未”：n = 10，976），使用但在过去12个月内没有（“以前”：n = 2990），或在过去12个月内使用（“当前”：n = 712）。自我报告的认知使用执行功能指数进行测量。使用酒精使用障碍和相关残疾访谈计划表-5获得Maritime和物质使用特征。协变量包括人口统计学、精神健康和残疾以及精神和物质使用障碍共病。使用横截面数据的一般线性模型，我们发现当前用户，特别是那些患有大麻使用障碍的用户，报告的认知比从未或以前的用户更差，但这些影响的幅度很小。在以前和现在的用户中，过去使用的时间越长，认知越差。过去12个月内频繁使用与当前用户的认知较差相关，但与每月或每周使用者相比，每日使用者的认知更好。因此，大麻的使用可能会影响老年人自我报告的认知，尽管这些影响可能是微妙的，特定于特定的使用特征，并可能受到自我意识缺陷的影响。未来的工作使用客观的措施，如神经心理学测试或神经影像学可能会更好地阐明这些影响。
Marijuana use among older adults is on an unprecedented rise, yet little is known about its effects on cognition in this population where, due to advanced age, risk for cognitive decline is high. Thus, we investigated whether marijuana use and use characteristics were associated with self-reported cognition among older adults ages >= 50 years using the National Epidemiologic Survey on Alcohol and Related Conditions-III. Respondents either had never used marijuana ("never": n = 10,976), used but not in the past 12 months ("former": n = 2990), or used in the past 12 months ("current": n = 712). Self-reported cognition was measured using the Executive Function Index. Marijuana and substance use characteristics were obtained using the Alcohol Use Disorder and Associated Disabilities Interview Schedule-5. Covariates included demographics, mental health and disability, and comorbid mental and substance use disorder. Using general linear models of cross-sectional data, we found that current users, particularly those with cannabis use disorder, reported worse cognition than never or former users, but these effects were small in magnitude. Among both former and current users, greater duration of past use was associated with worse cognition. Frequent use within the past 12 months was associated with worse cognition among current users, but daily users reported better cognition compared to monthly or weekly users. Thus, marijuana use may impact self-reported cognition in older adulthood, although these effects may be subtle, specific to particular use characteristics, and possibly affected by self-awareness of deficits. Future work using objective measures such as neuropsychological testing or neuroimaging may better elucidate these effects.