ATE1-Mediated Post-Translational Arginylation Is an Essential Regulator of Eukaryotic Cellular Homeostasis.
ATE1-Mediated Post-Translational Arginylation Is an Essential Regulator of Eukaryotic Cellular Homeostasis.
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DOI：
10.1021/acschembio.0c00677
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发表时间：
2020-12-18
影响因子：
4
通讯作者：
Smith AT
中科院分区：
文献类型：
--
作者：
Van V;Smith AT
精氨酰化是一种蛋白质翻译后修饰，由乙酰氨基转移酶（ATE 1）催化，这是所有真核生物中保守的关键酶。精氨酸化是Arg N-降解决定子途径中的关键步骤，Arg N-降解决定子途径是将蛋白质的泛素依赖性降解与其N-末端氨基酸侧链的身份联系起来的分级细胞信号传导途径。ATE 1催化的腺苷酸化的保真度是必要的，因为这种翻译后修饰调节几个基本的生物学过程，如心血管成熟，染色体分离，甚至应激反应。虽然ATE 1催化的乙酰化过程已在细胞水平上进行了详细研究，但关于这种重要酶的结构、作用机制及其调控仍有许多未知之处。在这项工作中，我们详细介绍了ATE 1催化的乙酰化的知识现状，我们讨论了正在进行的和未来的方向，将揭示这种重要的真核细胞调节剂的结构和机制的细节。
Arginylation is a protein post-translational modification catalyzed by arginyl-tRNA transferases (ATE1s), which are critical enzymes conserved across all eukaryotes. Arginylation is a key step in the Arg N-degron pathway, a hierarchical cellular signaling pathway that links the ubiquitin-dependent degradation of a protein to the identity of its N-terminal amino acid side chain. The fidelity of ATE1-catalyzed arginylation is imperative, as this post-translational modification regulates several essential biological processes such as cardiovascular maturation, chromosomal segregation, and even the stress response. While the process of ATE1-catalyzed arginylation has been studied in detail at the cellular level, much remains unknown about the structure of this important enzyme, its mechanism of action, and its regulation. In this work, we detail the current state of knowledge on ATE1-catalyzed arginylation, and we discuss both ongoing and future directions that will reveal the structural and mechanistic details of this essential eukaryotic cellular regulator.
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