Cross-cultural validation of the Japanese functional assessment of cancer therapy-anemia (FACT-An)
Cross-cultural validation of the Japanese functional assessment of cancer therapy-anemia (FACT-An)
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DOI：
10.1272/jnms.71.314
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发表时间：
2004-10-01
影响因子：
1
通讯作者：
Kudoh, Shoji
中科院分区：
文献类型：
--
作者：
Yoshimura, Akinobu;Kobayashi, Kunihiko;Kudoh, Shoji
背景资料：癌症治疗功能评估-贫血（FACT-An）问卷由一个名为癌症治疗功能评估（FACT-G）的一般指标和贫血额外关注子量表的核心问卷组成，在英语文化中开发。先前报道了日本FACT-G的验证（Fumimoto等人，2001），并且在本报告中，对子量表进行了跨文化验证。研究方法：日语版本是通过在慢性疾病治疗功能评估（FACIT）多语言翻译项目中使用的迭代向前-向后翻译序列开发的。在评价心理测量学绩效时，采用探索性因素分析考察了其结构效度，并用Cronbach’s α系数进行了验证。结果：180例肺癌患者接受FACT-An治疗。使用贫血子量表的20个项目，因子分析提取了疲劳、胸部状况、活动和头痛四个因子。当分析为两个提取的因素，疲劳，胸部状况和头痛合并为一个主要因素，虽然活动的次要因素仍然存在。20个项目中的13个构成疲劳附加关注子量表。疲劳子量表（0.93）和贫血子量表（0.88）的Cronbach α系数证实，尽管这些子量表的项目侧重于贫血或疲劳的不同方面，但每个子量表都是一维的。东部肿瘤协作组体能状态评分（ECOG PSR）与贫血子量表（-0.50）或疲劳子量表（-0.48）之间的斯皮尔曼相关系数值中等，表明了临床有效性。结论：疲劳子量表和贫血子量表在日本均有效，表明FACT-An是一种适用于不同文化的工具，尤其适用于日本癌症人群。
Background: The Functional Assessment of Cancer Therapy-Anemia (FACT-An) questionnaire, which consists of a core questionnaire named the General Measure of the Functional Assessment of Cancer Therapy (FACT-G) and the Anemia additional concerns subscale, was developed in an English-speaking culture. The validation of the Japanese FACT-G was reported previously (Fumimoto et al., 2001), and, in this report, a cross-cultural validation for the subscale was performed. Methods: The Japanese version was developed through an iterative forward-backward translation sequence used throughout the Functional Assessment of Chronic Illness Therapy (FACIT) Multilingual Translation Project. In evaluating psychometric performance, its construct validity was investigated by exploratory factor-analyses, and confirmed by Cronbach's alpha coefficient. Results: The FACT-An was given to 180 patients with lung cancer. Using the 20 items of the Anemia subscale, a factor analysis extracted four factors of fatigue, chest condition, activities and headache. When analyzed as two extracted factors, fatigue, chest condition and headache were combined to be a major factor, although the minor factor of activities still remained. Thirteen of the 20 items construct the Fatigue additional concerns subscale. Cronbach's alpha coefficients for the Fatigue subscale (0.93) and the Anemia subscale (0.88) confirmed that, although these subscales had items that focus on different aspects of anemia or fatigue, each subscale was unidimensional. Clinical validity was indicated by moderate values of Spearman's correlation coefficients between Eastern Cooperative Oncology Group performance status rating (ECOG PSR) and the Anemia subscale (- 0.50) or the Fatigue subscale (-0.48). Conclusion: Both the Fatigue subscale and the Anemia subscale are valid in Japan, indicating that FACT-An is an instrument that is applicable across cultures and particularly with a Japanese cancer population.