Impact of age and duration on sight-threatening retinopathy in South Asians and Caucasians attending a diabetic clinic
Impact of age and duration on sight-threatening retinopathy in South Asians and Caucasians attending a diabetic clinic
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DOI：
10.1038/sj.eye.6700629
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发表时间：
2004-03-01
期刊：
影响因子：
3.9
通讯作者：
Mahomed, I
中科院分区：
文献类型：
--
作者：
Pardhan, S;Gilchrist, J;Mahomed, I
目的检测在医院糖尿病诊所就诊的亚洲人和高加索人中的糖尿病视网膜病变，并评估重要危险因素对视力威胁视网膜病变概率的影响。方法对500名在规定时间内就诊的糖尿病患者(亚洲人268人，高加索人232人)进行糖尿病视网膜病变的严重程度检查。比较两组视力威胁视网膜病变(STR)的存在情况。对年龄、病程、高血压等重要危险因素与两个种族发生STR的概率进行分析。结果亚洲人STR发生率明显高于亚洲人。单变量分析显示，年龄、病程、种族、性别和需要胰岛素的状况与STR显著相关。多因素Logistic回归分析显示，STR与种族、年龄和糖尿病病程显著相关，变量间无显著交互作用。Logistic回归模型通过一个12.5年差异因素预测亚洲人与高加索人的STR相匹配，即在相同的STR水平下，高加索人比亚洲人年长12.5岁或病程长12.5年。结论调整年龄和病程后，在布拉德福德糖尿病门诊就诊的亚洲糖尿病患者发生STR的概率显著高于高加索人(优势比=3.184，P
Aims To examine diabetic retinopathy in Asians and Caucasians attending a hospital diabetic clinic and to evaluate the impact of the significant risk factors on the probability of sight-threatening retinopathy.Methods A total of 500 diabetic patients ( 268 Asians, 232 Caucasians) who attended a diabetic clinic within a defined time period were examined for severity of diabetic retinopathy. The existence of sight-threatening retinopathy (STR) was compared in the two groups. Significant risk factors such as age, duration and hypertension were analysed against the probability of STR in each of the two races.Results Asians demonstrated significantly higher rates of STR. Univariate analysis showed age, duration, race, gender, and insulin-requiring status to be significantly associated with STR. Multivariate logistic regression showed a significant association of STR with race, age and duration of diabetes, with no significant interaction effects between variables. The logistic regression model predicted STR in Asians to be matched to that in Caucasians by a 12.5-year difference factor; that is, Caucasians were older by 12.5 years or had a 12.5-year longer duration than Asians for the same level of STR.Conclusions After adjusting for age and duration of diabetes, the probability of STR in Asian diabetic patients attending the diabetic clinics in Bradford is significantly higher than that in Caucasians ( odds ratio = 3.184, P