Positive correlation between peripheral blood granulocyte oxidative status and level of anxiety in mice
Positive correlation between peripheral blood granulocyte oxidative status and level of anxiety in mice
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DOI：
10.1016/j.ejphar.2007.02.055
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发表时间：
2007-06-14
影响因子：
5
通讯作者：
Soulimani, Rachid
中科院分区：
文献类型：
--
作者：
Bouayed, Jaouad;Rammal, Hassan;Soulimani, Rachid
氧化应激与许多急慢性疾病有关，包括癌症、心血管疾病和神经退行性疾病。我们使用行为光/暗选择测试研究了外周粒细胞胞内活性氧水平与小鼠焦虑水平的关系。我们的研究结果表明，外周血粒细胞细胞内氧化还原状态与焦虑相关行为的不同参数，包括潜伏期（R-2 =0.737, P < 0.001），在点燃盒中累计花费的时间（R-2 = 0.612, P < 0.01）和进入点燃盒的次数（R-2 = 0.661, P < 0.01）之间存在线性且显著的关系。这些结果表明外周氧化状态与小鼠焦虑水平之间存在正相关关系。(c) 2007 Elsevier B.V.版权所有
Oxidative stress is involved in many acute and chronic diseases including cancer, cardiovascular disorders and neurodegenerative diseases. We studied the relationship between the level of intracellular reactive oxygen species in peripheral granulocytes and the estimated anxiety level of mice using the behavioral light/dark choice test. Our results indicate a linear and significant relationship between the intracellular redox status of peripheral blood granulocytes and different parameters of anxiety-related behavior including latency time (R-2 =0.737, P < 0.001), cumulative time spent in the lit box (R-2 = 0.612, P < 0.01) and number of entries into the lit box (R-2 = 0.661, P < 0.01). These results suggest a positive relationship between peripheral oxidative status and level of anxiety in mice. (c) 2007 Elsevier B.V. All rights reserved.