Alcohol as a risk factor for global burden of disease
Alcohol as a risk factor for global burden of disease
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DOI：
10.1159/000072222
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发表时间：
2003-10-01
影响因子：
3.9
通讯作者：
Jernigan, D
中科院分区：
文献类型：
--
作者：
Rehm, J;Room, R;Jernigan, D
目的：对 2000 年全球因酒精造成的疾病负担进行定量估计。设计：二次数据分析。测量：包括酒精暴露的两个维度：平均饮酒量和饮酒模式。还有两个主要结果指标：死亡率，即死亡人数；伤残调整生命年（DALY），即因过早死亡或残疾而损失的生命年数。所有估计数均按性别、年龄组和世卫组织区域分别编制。研究结果：酒精会造成相当大的疾病负担：2000 年，全球死亡人数的 3.2% 和全球伤残调整生命年 (DALY) 的 4.0% 可归因于这种接触。这两种结果因性别和地区的不同而存在显着差异。此外，疾病类别和结果类型也存在差异；特别是，无意伤害对酒精造成的死亡负担影响最大，而神经精神疾病对酒精造成的疾病负担影响最大。讨论/结论：讨论了基本假设，并给出了为什么尽管全球酒精造成相当大的负担，但估计值仍应被视为保守的原因。版权所有 (C) 2003 S. Karger AG，巴塞尔。
Aim:To make quantitative estimates of the burden of disease attributable to alcohol in the year 2000 on a global basis. Design: Secondary data analysis. Measurements: Two dimensions of alcohol exposure were included: average volume of alcohol consumption and patterns of drinking. There were also two main outcome measures: mortality, i.e. the number of deaths, and disability-adjusted life years (DALYs), i.e. the number of years of life lost to premature mortality or to disability. All estimates were prepared separately by sex, age group and WHO region. Findings: Alcohol causes a considerable disease burden: 3.2% of the global deaths and 4.0% of the global DALYs in the year 2000 could be attributed to this exposure. There were marked differences by sex and region for both outcomes. In addition, there were differences by disease category and type of outcome; in particular, unintentional injuries contributed most to alcohol-attributable mortality burden while neuropsychiatric diseases contributed most to alcohol-attributable disease burden. Discussion/Conclusions:The underlying assumptions are discussed and reasons are given as to why the estimates should still be considered conservative despite the considerable burden attributable to alcohol globally. Copyright (C) 2003 S. Karger AG, Basel.