Coupling of the HPA and HPG axes in the context of early life adversity in incarcerated male adolescents.
Coupling of the HPA and HPG axes in the context of early life adversity in incarcerated male adolescents.
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DOI：
10.1002/dev.21231
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发表时间：
2015-09
影响因子：
2.2
通讯作者：
Shirtcliff EA
中科院分区：
文献类型：
--
作者：
Dismukes AR;Johnson MM;Vitacco MJ;Iturri F;Shirtcliff EA
早期生活逆境的影响可以在整个生命周期中观察到，下丘脑-垂体-肾上腺轴（HPA）和下丘脑-垂体-性腺轴（HPG）可能是这种现象背后的机械中介。目前的研究调查了50名年龄在12-18岁之间的青少年男性，他们住在一个最高安全级别的惩教和治疗场所。每天收集唾液样本5次，持续两天，检测皮质醇、睾酮和脱氢表雄酮。青少年完成了半结构化的生活压力访谈和儿童虐待的自我报告，以指数逆境。当年轻人的睾丸激素水平较高时，他们的皮质醇和脱氢表雄酮水平也较高，这表明HPA- HPG轴正“耦合”。此外，经历更大生活逆境的儿童HPA-HPG轴的耦合更紧密。其他分析提示，耦合可能主要是由HPG轴功能驱动的。结果表明，在被监禁青少年中，特别是那些生活压力最大的青少年中，HPA-HPG轴存在正耦合。
The effects of early life adversity can be observed across the lifespan, and the Hypothalamic-Pituitary-Adrenal (HPA) and Hypothalamic-Pituitary-Gonadal (HPG) axes could be mechanistic intermediaries underlying this phenomenon. The current study examined fifty adolescent males aged 12–18 in a maximum-security correctional and treatment setting. Saliva samples were collected five times a day for two day and assayed for cortisol, testosterone and DHEA. Youth completed semi-structured life stress interviews and self-reports of child maltreatment to index adversity. When youth had higher testosterone levels, they had higher cortisol and DHEA levels, indicating positive “coupling” of the HPA- HPG axes. In addition, children experiencing greater life adversity had tighter coupling of the HPA-HPG axes. Additional analyses hint that coupling may be driven largely by HPG axis functioning. Results indicate that positive coupling of the HPA-HPG axis is observed within incarcerated adolescents, especially for those with the greatest life stress.