c-Jun induction is independent of early growth response factor during cerebellar granule neuron apoptosis
c-Jun induction is independent of early growth response factor during cerebellar granule neuron apoptosis
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小脑颗粒神经元凋亡过程中 c-Jun 诱导独立于早期生长反应因子
DOI：
10.1097/wnr.0b013e32834e7d69
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发表时间：
2012-01
期刊：
影响因子：
1.7
通讯作者：
Li Mingtao
中科院分区：
文献类型：
--
作者：
Song Bin;Xie Bo;Wang Chong;Li Mingtao
早期生长反应因子1 （Early growth response factor 1, Egr-1）在小脑颗粒神经元活性剥夺依赖性凋亡过程中被诱导，在神经元凋亡中起关键作用。有人提出c-Jun位于小脑颗粒神经元中依赖egr的促凋亡信号级联的下游。然而，我们的数据显示，无论是使用显性阴性突变体抑制Egr活性，还是使用小干扰RNA特异性沉默Egr-1，都不能抑制小脑颗粒神经元活性剥夺后c-Jun的激活和表达。此外，两种抑制剂米霉素A和色霉素A3通过选择性取代富含gc的dna结合转录因子（包括Egr家族的转录因子）来抑制转录，并没有减弱神经元凋亡过程中c-Jun的激活和表达。我们得出结论，在活动剥夺引起的小脑颗粒神经元凋亡过程中，c-Jun的诱导与Egr无关。
Early growth response factor 1 (Egr-1) is induced during activity deprivation-dependent apoptosis in cerebellar granule neurons and plays a critical role in neuronal apoptosis. It has been proposed that c-Jun lies downstream of the Egr-dependent proapoptotic signaling cascade in cerebellar granule neurons. However, our data show that neither suppressing Egr activity using a dominant-negative mutant nor specifically silencing Egr-1 using small interfering RNA inhibited the activation and expression of c-Jun after activity deprivation in cerebellar granule neurons. Furthermore, two inhibitors, mithramycin A and chromomycin A3, which repressed transcription by selectively displacing GC-rich DNA-binding transcription factors (including those of the Egr family), did not attenuate the activation and expression of c-Jun during neuronal apoptosis. We conclude that c-Jun induction is independent of Egr during apoptosis induced by activity deprivation in cerebellar granule neurons.
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影响因子：
8
作者：
Yamaguchi, H.;Chen, C-T;Chou, C-K;Pal, A.;Bornmann, W.;Hortobagyi, G. N.;Hung, M-C
通讯作者：
Hung, M-C
dp5/HRK 是 c-Jun 靶基因，是小脑颗粒神经元缺钾诱导细胞凋亡所必需的
影响因子：
4.8
作者：
Ma, Chi;Ying, Chunyi;Li, Mingtao
通讯作者：
Li, Mingtao
影响因子：
4.7
作者：
Raivich, Gennadij
通讯作者：
Raivich, Gennadij
影响因子：
4.7
作者：
Tureyen, Kudret;Brooks, Nathaniel;Vemuganti, Raghu
通讯作者：
Vemuganti, Raghu
影响因子：
21.3
作者：
Virolle, T;Adamson, ED;de Belle, I
通讯作者：
de Belle, I