Long-term follow-up of patients with atopic keratoconjunctivitis.
Long-term follow-up of patients with atopic keratoconjunctivitis.
复制标题
特应性角结膜炎患者的长期随访。
DOI：
10.1016/s0161-6420(98)94017-9
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发表时间：
1998
期刊：
影响因子：
13.7
通讯作者：
C. Foster
中科院分区：
文献类型：
--
作者：
William J. Power;İ. Tuğal;İ. Tuğal;C. Foster
本研究旨在回顾特应性角膜结膜炎患者的临床表现、治疗方法、组织病理学表现及并发症。设计：采用回顾性队列研究方法，对20例特应性角结膜炎患者的病史进行回顾，并对其进行至少3年的随访。主要观察指标结膜及角膜并发症、手术前后视力及结膜活检的组织病理学特征。结果70%的患者发生明显的角膜病变，60%的患者发生角膜新生血管，25%的患者发生角膜新生血管，25%的患者发生角膜新生血管，20%的患者发生粘连。11例(12眼)患者行穿透性角膜移植(3例为构造目的，8例为视力恢复目的)。术后4只眼视力提高4行以上，2只眼提高2行，5只眼保持不变，1只眼角膜移植后视力下降2行。7例(9只眼)患者接受了白内障手术，其中6例(8只眼)视力提高了4行以上。结论特应性角膜结膜炎是一种潜在的致盲疾病，可因角膜并发症而导致视力不良。选择性手术干预可能是有益的，可以考虑在炎症得到良好控制的患者中进行。
OBJECTIVEThis study aimed to review the presenting features, treatment administered to, histopathologic findings, and complications encountered in a cohort of patients with atopic keratoconjunctivitis.DESIGNThe study design was a retrospective cohort series.PARTICIPANTSThe medical records of 20 patients with atopic keratoconjunctivitis and a minimum follow-up of 3 years were reviewed.MAIN OUTCOME MEASURESConjunctival and corneal complications, visual acuity before and after surgery, and histopathologic features on conjunctival biopsy were measured.RESULTSSignificant keratopathy developed in 70% of patients, corneal neovascularization in 60%, fornix fore-shortening in 25%, and symblepharon in 20% during the course of their disease. Eleven patients (12 eyes) required penetrating keratoplasty (3 for tectonic purposes and 8 for visual rehabilitation). Vision improved by four or more lines of Snellen acuity in four eyes, improved by two lines in two eyes, remained the same in five eyes, and worsened by two lines in one eye after keratoplasty. Cataract surgery was performed in seven patients (nine eyes) with vision improving by four or more lines in six patients (eight eyes).CONCLUSIONAtopic keratoconjunctivitis is a potentially blinding disease that may result in a poor visual outcome as a result of corneal complications. Elective surgical intervention may be of benefit and can be considered in those patients whose inflammation is well controlled.