ASSISTED VENTILATION FOR PATIENTS WITH CYSTIC-FIBROSIS
ASSISTED VENTILATION FOR PATIENTS WITH CYSTIC-FIBROSIS
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DOI：
10.1001/jama.239.18.1851
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发表时间：
1978-01-01
影响因子：
120.7
通讯作者：
DISANTAGNESE, PA
中科院分区：
文献类型：
--
作者：
DAVIS, PB;DISANTAGNESE, PA
囊性纤维化（CF）患者[46]，1个月。至32岁，有51次辅助通气。35例（69%）在机械通气1-395天后死亡，6例（12%）在停止辅助通气治疗后1-42天死于医院。仅3例患者出院后存活超过1年。这些结果比其他原因的慢性阻塞性肺疾病患者报告的结果差得多，这可能是因为CF的自然史和对治疗的反应不同。CF患者尽管接受了最佳治疗，但病情仍进行性恶化，并且对抗生素和物理治疗不再有反应，因此不适合机械通气。偶尔发生急性呼吸衰竭的基线状态良好的患者应考虑辅助通气。
Patients [46] with cystic fibrosis (CF), 1 mo. to 32 yr of age, had 51 episodes of assisted ventilation. Thirty-five (69%) died after 1-395 days of mechanical ventilation and 6 others (12%) died in the hospital 1-42 days after assisted ventilation therapy was discontinued. Only 3 patients survived longer than 1 yr after discharge. These results are much poorer than those reported for patients with chronic obstructive pulmonary disease of other causes probably because of the different natural history and response to therapy in CF. Patients with CF whose conditions progressively deteriorated despite optimal therapy and no longer respond to antibiotic and physical therapy are not good candidates for mechanical ventilation. The occasional patient with good baseline status in whom acute respiratory failure develops should be considered for assisted ventilation.