Antidepressant-like effects of a cocoa polyphenolic extract in Wistar-Unilever rats
Antidepressant-like effects of a cocoa polyphenolic extract in Wistar-Unilever rats
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DOI：
10.1179/147683008x344165
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发表时间：
2008-12-01
影响因子：
3.6
通讯作者：
Javelot, Herve
中科院分区：
文献类型：
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作者：
Messaoudi, Michael;Bisson, Jean-Francois;Javelot, Herve
抑郁症是影响世界约12%人口的主要公共卫生问题。药物是存在的，但它们有很多副作用。在过去的几年里，天然物质（如类黄酮）已被用于治疗这类疾病。可可多酚提取物是一种复杂的化合物，从未经烘焙的可可豆中提取，含有高水平的类黄酮。采用大鼠强迫游泳试验评价可可多酚提取物的抗抑郁样作用。可可多酚提取物在24 mg/kg/14天和48 mg/kg/14天的剂量下均显著缩短了静止时间，但在野外测试的两种剂量均未观察到运动功能障碍的变化。亚慢性治疗后的强迫游泳测试和额外的运动活动测试的结果证实了强迫游泳测试模型中可可多酚提取物的抗抑郁样作用是特异性的。进一步推测，这种作用可能与其活性多酚含量有关。
Depression is a major public health problem affecting about 12% of the world population. Drugs exist but they have many side effects. In the last few years, natural substances (e. g. flavonoids) have been tested to cure such disorders. Cocoa polyphenolic extract is a complex compound prepared from non-roasted cocoa beans containing high levels of flavonoids. The antidepressant-like effect of cocoa polyphenolic extract was evaluated using the forced swimming test in rats. Cocoa polyphenolic extract significantly reduced the duration of immobility at both doses of 24 mg/kg/14 days and 48 mg/kg/14 days, although no change of motor dysfunction was observed with the two doses tested in the open field. The results of the forced swimming test after a subchronic treatment and after an additional locomotor activity test confirm the assumption that the antidepressant-like effect of cocoa polyphenolic extract in the forced swimming test model is specific. Further, it can be speculated that this effect might be related to its content of active polyphenols.