A Randomized Controlled Trial of Green Tea Extract Supplementation and Mammographic Density in Postmenopausal Women at Increased Risk of Breast Cancer.
A Randomized Controlled Trial of Green Tea Extract Supplementation and Mammographic Density in Postmenopausal Women at Increased Risk of Breast Cancer.
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DOI：
10.1158/1940-6207.capr-17-0187
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发表时间：
2017-12
期刊：
影响因子：
--
通讯作者：
Kurzer MS
中科院分区：
文献类型：
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作者：
Samavat H;Ursin G;Emory TH;Lee E;Wang R;Torkelson CJ;Dostal AM;Swenson K;Le CT;Yang CS;Yu MC;Yee D;Wu AH;Yuan JM;Kurzer MS
流行病学和动物研究表明，绿色茶对乳腺癌有保护作用。然而，根本的机制还不清楚。我们进行了一项随机、双盲、安慰剂对照的II期临床试验，以研究补充绿色茶提取物（GTE）是否会改变乳腺摄影密度（MD），作为一种潜在机制，涉及1,075名健康绝经后妇女。分配到治疗组的妇女每天服用4粒含有1，315 mg总儿茶素的脱咖啡因GTE胶囊，包括843 mg表没食子儿茶素-3-没食子酸酯（EGCG），持续12个月。使用计算机辅助方法（Madena）评估932例完成者（GTE组462例，安慰剂组470例）在基线和第12个月时间点的数字乳腺X线照片中的MD。补充GTE 12个月并没有显着改变百分比MD（PMD）或绝对MD在所有妇女。在年轻女性（50-55岁）中，与安慰剂相比，补充GTE可显著降低PMD 4.40%，从干预前到干预后PMD增加1.02%（P = 0.05），但对老年女性无影响（P相互作用= 0.07）。在按儿茶酚-O-甲基转移酶基因型或体重指数水平分层的其他妇女亚组中，补充GTE并没有引起MD的变化。总之，1年补充高剂量的表没食子儿茶素没食子酸酯对所有女性的MD指标没有显著影响，但减少了年轻女性的PMD，这是一种与他莫昔芬相似的年龄依赖性效应。进一步研究绿色茶摄入量对年轻女性乳腺癌风险的潜在化学预防作用是必要的。
Epidemiologic and animal studies suggest a protective role of green tea against breast cancer. However, the underlying mechanism is not understood. We conducted a randomized, double-blinded, placebo-controlled phase II clinical trial to investigate whether supplementation with green tea extract (GTE) modifies mammographic density (MD), as a potential mechanism, involving 1,075 healthy postmenopausal women. Women assigned to the treatment arm consumed daily 4 decaffeinated GTE capsules containing 1,315 mg total catechins, including 843 mg epigallocatechin-3-gallate (EGCG) for 12 months. A computer-assisted method (Madena) was used to assess MD in digital mammograms at baseline and month 12 time points in 932 completers (462 in GTE and 470 in placebo). GTE supplementation for 12 months did not significantly change percent MD (PMD) or absolute MD in all women. In younger women (50–55 years), GTE supplementation significantly reduced PMD by 4.40% as compared with the placebo with a 1.02% PMD increase from pre- to postintervention (P = 0.05), but had no effect in older women (Pinteraction = 0.07). GTE supplementation did not induce MD change in other subgroups of women stratified by catechol-O-methyltransferase genotype or level of body mass index. In conclusion, 1-year supplementation with a high dose of EGCG did not have a significant effect on MD measures in all women, but reduced PMD in younger women, an age-dependent effect similar to those of tamoxifen. Further investigation of the potential chemopreventive effect of green tea intake on breast cancer risk in younger women is warranted.