Family History Studies: VII. Manic Depressive Disease Versus Depressive Disease
Family History Studies: VII. Manic Depressive Disease Versus Depressive Disease
复制标题
家族史研究：七。
DOI：
--
复制
发表时间：
1970
影响因子：
10.5
通讯作者：
P. Clayton
中科院分区：
文献类型：
--
作者：
R. Cadoret;G. Winokur;P. Clayton
在过去的20年里，Kraepelin（1913）定义的躁狂抑郁症的统一性受到了研究者的质疑，他们提出了临床和遗传学证据，证明这种疾病是异质性的，至少包含两个离散的组（Leonhard，1957;佩里斯，1966）。在这些群体之一中，躁狂症发生，患者在疾病过程中表现出躁狂和抑郁两个阶段。大多数研究者将这一组定为双相障碍（Leonhard，1957;佩里斯，1966）。在另一组中，只有抑郁发作，这被一些人称为单极组（佩里斯，1966），主要对应于莱昂哈德（1957）的“单极”组。在本文中，我们将使用术语单极始终指定一种情感疾病，其中只有抑郁症发生。
During the past twenty years, the unity of manic-depressive disease as defined by Kraepelin (1913) has been questioned by investigators who have presented clinical and genetic evidence that the disease is heterogeneous and contains at least two discrete groups (Leonhard, 1957; Perris, 1966). In one of these groups mania occurs and patients exhibit both manic and depressive phases during the course of their illness. This group has been designated bipolar by most investigators (Leonhard, 1957; Perris, 1966). In the other group there are only episodes of depression, and this has been designated the unipolar group by some (Perris, 1966) and corresponds largely to the ‘monopolar’ group of Leonhard (1957). In this paper we shall use the term unipolar throughout to designate an affective illness in which only depression occurs.