Cigarette smoking and survival after ovarian cancer diagnosis
Cigarette smoking and survival after ovarian cancer diagnosis
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DOI：
10.1158/1055-9965.epi-06-0592
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发表时间：
2006-12-01
影响因子：
3.8
通讯作者：
Webb, Penelope M.
中科院分区：
文献类型：
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作者：
Nagle, Christina M.;Bain, Christopher J.;Webb, Penelope M.
我们研究了676名患有浸润性上皮性卵巢癌的妇女吸烟与卵巢癌存活率之间的关系，这些妇女是在20世纪90年代初纳入病例对照研究的。有关吸烟和其他个人和生殖因素的信息是在确诊时通过个人面谈获得的。COX比例风险模型用于评估吸烟与卵巢癌死亡时间之间的关系。确诊的吸烟者比从未吸烟的女性更有可能过早死亡[调整后的危险比(HR)，1.36；95%可信区间(95%CI)，1.01-1.84]。那些吸烟年限超过30年(HR为1.94；95%CI，1.41-2.66)和每天吸烟次数更多(HR，1.93；95%CI，1.37-2.73)的人死亡风险增加。所有这些关联在患有晚期疾病的女性中都更强(现在吸烟者与从不吸烟者的HR为1.58；95%CI为1.15-2.18)。在调整了终生吸烟暴露后，戒烟时间对存活率几乎没有影响。这些结果验证和扩展了最近的发现，并表明病前吸烟与卵巢癌患者的预后更差有关。
We have examined the association between cigarette smoking and ovarian cancer survival in 676 women with invasive epithelial ovarian cancer, recruited into a case-control study in the early 1990s. Information about cigarette smoking and other personal and reproductive factors was obtained from a personal interview at the time of diagnosis. Cox proportional hazards models were used to evaluate the association between cigarette smoking and time to ovarian cancer death. Current smokers at diagnosis were more likely to die early than women who had never smoked [adjusted hazard ratio (HR), 1.36; 95% confidence interval (95% CI), 1.01-1.84]. Increased risks of dying were greater among those who had accumulated more pack-years of smoking (HR for 30+ pack-years compared with never smokers, 1.94; 95% Cl, 1.41-2.66) and smoked more cigarettes per day (HR, 1.93; 95% CI, 1.37-2.73). All these associations were stronger among women with late-stage disease (HR for current versus never smokers, 1.58; 95% Cl, 1.15-2.18). Time since quitting had little effect on survival after adjusting for lifetime smoking exposure. These results validate and extend recent findings and suggest that premorbid cigarette smoking is related to worse outcome in ovarian cancer patients.