NK cells stimulate recruitment of CXCR3+ T cells to the brain during Plasmodium berghei-mediated cerebral malarial
NK cells stimulate recruitment of CXCR3+ T cells to the brain during Plasmodium berghei-mediated cerebral malarial
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DOI：
10.4049/jimmunol.178.9.5779
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发表时间：
2007-05-01
影响因子：
4.4
通讯作者：
Schofield, Louis
中科院分区：
文献类型：
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作者：
Hansen, Diana S.;Bernard, Nicholas J.;Schofield, Louis
NK细胞是细胞毒性淋巴细胞，也分泌调节细胞因子，因此可以影响适应性免疫反应。NK细胞的功能在很大程度上是由存在于一个名为NK复合物的基因组区域的基因控制的。NK复合体是伯氏疟原虫ANKA介导的小鼠脑型疟疾发病机制的遗传决定因素。在这项研究中，我们发现NK细胞是脑疟疾疾病诱导和寄生虫病控制所必需的。发现NK细胞浸润脑疟疾感染小鼠的大脑。NK细胞耗竭导致伯氏疟原虫感染动物的T细胞向大脑募集受到抑制。NK细胞缺失小鼠对ifn - γ诱导蛋白10的反应显示CXCR3表达下调，T细胞迁移显著减少，表明该趋化因子通路在导致脑疾病和死亡的白细胞运输中起重要作用。中华免疫学杂志，2007,18(2):579 - 588。
NK cells are cytotoxic lymphocytes that also secrete regulatory cytokines and can therefore influence adaptive immune responses. NK cell function is largely controlled by genes present in a genomic region named the NK complex. It has been shown that the NK complex is a genetic determinant of murine cerebral malaria pathogenesis mediated by Plasmodium berghei ANKA. In this study, we show that NK cells are required for cerebral malaria disease induction and the control of parasitemia. NK cells were found infiltrating brains of cerebral malaria-affected mice. NK cell depletion resulted in inhibition of T cell recruitment to the brain of P. berghei-infected animals. NK cell-depleted mice displayed down-regulation of CXCR3 expression and a significant reduction of T cells migrating in response to IFN-gamma-inducible protein 10, indicating that this chemokine pathway plays an essential role in leukocyte trafficking leading to cerebral disease and fatalities. The Journal of Immunology, 2007, 178: 5779-5788.