Carotid body amine levels in goats exposed to hypoxia or hypercapnia.
Carotid body amine levels in goats exposed to hypoxia or hypercapnia.
复制标题
暴露于缺氧或高碳酸血症的山羊的颈动脉体胺水平。
DOI：
10.1016/0304-3940(89)90821-5
复制
发表时间：
1989
影响因子：
2.5
通讯作者：
Bisgard,GE
中科院分区：
文献类型：
--
作者：
Engwall,MJ;OlsonJr,EB;Bisgard,GE
颈动脉小体(CB)含有大量的单胺类物质。有相当多的证据表明，颈动脉小体(CB)化学感受器的功能可能受一种或几种单胺的调节。为了测试刺激CB的条件是否会改变这些单胺类物质的CB含量，我们测量了山羊颈动脉小体在常氧-常二氧化碳、低氧-常压和常氧-高二氧化碳混合气体作用4h后去甲肾上腺素、多巴胺、5-羟吲哚-乙酸和5-羟色胺的含量。我们发现，与暴露在测试气体中有关的这些胺的水平没有持续的变化。这些发现不支持这样的假设，即CB中这些胺水平的变化是暴露于4h低氧的山羊颈动脉化学感受器活性随时间变化的原因。
The carotid body (CB) contains large amounts of several monoamines. There is considerable evidence that carotid body (CB) chemoreceptor function may be regulated by one or several of these monoamines. In order to test whether conditions stimulating the CB might change the CB content of these monoamines, we measured the norepinephrine, dopamine, 5-hydroxyindoleacetic acid, and 5-hydroxytryptamine content of carotid bodies collected from goats exposed to 4 h of either normoxic-normocapnic, hypoxic-normocapnic, or normoxic-hypercapnic gas mixtures. We found that there were no consistent changes in the levels of these amines associated with exposure to the test gases. These findings would not support the hypothesis that changes in these amine levels in the CB are responsible for the time-dependent changes in carotid chemoreceptor activity in goats exposed to 4 h of hypoxia.