Crustacean hyperglycemic hormone (CHH) neuropeptides family: Functions, titer, and binding to target tissues
Crustacean hyperglycemic hormone (CHH) neuropeptides family: Functions, titer, and binding to target tissues
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DOI：
10.1016/j.ygcen.2009.12.011
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发表时间：
2010-05-01
影响因子：
2.7
通讯作者：
Tsutsui, N.
中科院分区：
文献类型：
--
作者：
Chung, J. Sook;Zmora, N.;Tsutsui, N.
去除眼柄诱导蜕皮和繁殖，促进眼柄（ES），特别是终髓X器官和窦腺（MTXO SG）中调节物质的存在。基于PCR的克隆策略已经允许从眼柄和非眼柄组织中分离大量甲壳动物高血糖激素（CHH）神经肽家族的cDNA序列，例如，心包器官和前后肠然而，这些组织中翻译的相应神经肽，其循环浓度，作用模式和具体的生理功能尚未得到很好的描述。存在于MTXO-SG中的CHH神经肽的概况在十足类甲壳动物物种中可能不同，但它们可以基于结构同源性大体上分为两个亚组：（1）CHH和（2）蜕皮抑制激素（MIH）/下颌器官抑制激素（MOIH）/卵黄生成/性腺抑制激素（V/GIH）。CHH通常在应激条件下（体温过高和过低、缺氧和低盐度）升高动物的循环葡萄糖水平，具有多种靶组织和功能，如蜕皮类固醇生成、代谢调节和卵黄生成。最近，MIH，专门抑制蜕皮甾体激素在Y-器官，也有报道有一个额外的作用，在成年雌性甲壳类动物的卵黄发生，这表明一些CHH神经肽可能获得额外的调节作用，在成年阶段的生殖。本文综述了两种蟹类CHH和MIH在特定功能、时空表达、滴度、靶组织结合位点和第二信使水平上的调控作用。它进一步讨论了不同的调节作用，这些神经肽和这些神经肽的功能可塑性方面的生命阶段和物种特异性生理。(C)2010年爱思唯尔公司All rights reserved.
The removal of the eyestalk (s) induces molting and reproduction promoted the presence of regulatory substances in the eyestalk (ES), particularly medulla terminalis X-organ and the sinus gland (MTXO-SG). The PCR-based cloning strategies have allowed for isolating a great number of cDNAs sequences of crustacean hyperglycemic hormone (CHH) neuropeptides family from the eyestalk and non-eyestalk tissues, e.g., pericardial organs and fore- and hindguts. However, the translated corresponding neuropeptides in these tissues, their circulating concentrations, the mode of actions, and specific physiological functions have not been well described. The profiles of CHH neuropeptides present in the MTXO-SG may differ among decapod crustacean species, but they can be largely divided into two sub-groups on the basis of structural homology: (1) CHH and (2) molt-inhibiting hormone (MIH)/mandibular organ-inhibiting hormone (MOIH)/vitellogenesis/gonad-inhibiting hormone (V/GIH). CHH typically elevating the level of circulating glucose from animals under stressful conditions (hyper- and hypothermia, hypoxia, and low salinity) has multiple target tissues and functions such as ecdysteroidogenesis, osmoregulation, and vitellogenesis. Recently, MIH, known for exclusively suppressing ecdysteroidogenesis in Y-organs, is also reported to have an additional role in vitellogenesis of adult female crustacean species, suggesting that some CHH neuropeptides may acquire an extra regulatory role in reproduction at adult stage. This paper reviews the regulatory roles of CHH and MIH at the levels of specific functions, temporal and spatial expression, titers, their binding sites on the target tissues, and second messengers from two crab species: the blue crab, Callinectes sapidus, and the European green crab, Carcinus maenas. It further discusses the diverse regulatory roles of these neuropeptides and the functional plasticity of these neuropeptides in regard to life stage and species-specific physiology. (C) 2010 Elsevier Inc. All rights reserved.