Evidence that upregulation of serum IGF-1 concentration can trigger acceleration of diabetic retinopathy
Evidence that upregulation of serum IGF-1 concentration can trigger acceleration of diabetic retinopathy
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DOI：
10.1136/bjo.82.7.725
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发表时间：
1998-07-01
影响因子：
4.1
通讯作者：
Chantelau, E
中科院分区：
文献类型：
--
作者：
Chantelau, E
背景-慢性高血糖的急性降低可加速早期糖尿病视网膜病变。在毛瑞克综合征的青少年患者中，这一现象与血清IGF-1水平升高有关。目的：获得经强化胰岛素治疗后高血糖降低的成年胰岛素依赖型糖尿病患者血清IGF-I水平和视网膜病变状况的纵向资料。密切跟踪血糖、糖化血红蛋白(1c)、血清胰岛素样生长因子-I(IGF-I)水平、蛋白尿、视网膜病变和临床状态的变化。结果：将高血糖从16 mmol/L(相当于HbA(1c)>；11%)降至
Background-Acute reduction of chronic hyperglycaemia can accelerate early diabetic retinopathy. In adolescent patients with Mauriac's syndrome, this phenomenon is related to an upregulation of subnormal serum IGF-1 levels.Aim-To obtain longitudinal data on serum IGF-I and retinopathy status in poorly controlled adult insulin dependent (type I) diabetic patients without Mauriac's syndrome, in whom hyperglycaemia is reduced by intensive insulin therapy.Methods-Four patients with chronic severe insulin deficiency and early microangiopathy were studied prospectively. Changes in plasma glucose, HbA(1c), serum IGF-I levels, proteinuria, retinopathy, and clinical status were followed up closely.Results-Reducing hyperglycaemia from >16 mmol/l (equivalent to HbA(1c) >11%) to