CONSTITUTIONAL HEPARIN CO-FACTOR II DEFICIENCY ASSOCIATED WITH RECURRENT THROMBOSIS
CONSTITUTIONAL HEPARIN CO-FACTOR II DEFICIENCY ASSOCIATED WITH RECURRENT THROMBOSIS
复制标题
与复发性血栓形成相关的结构性肝素辅因子 II 缺乏
DOI：
10.1016/s0140-6736(85)92737-0
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
B. Boneu
中科院分区：
文献类型：
--
作者：
P. Sié;J. Pichon;D. Dupouy;B. Boneu
一名36岁男性复发性深静脉血栓形成和肝素辅助因子II （HC II）缺乏症的家庭被调查这种缺乏症。该缺陷作为常染色体显性性状遗传。4名家族成员HC II水平低，但只有先证者有血栓病史；然而，受影响的4人中有2人只有14岁和23岁。缺乏肝素并不影响患者接受治疗的肝素的抗凝作用。
The family of a 36-year-old man with recurrent deep venous thrombosis and heparin co-factor II (HC II) deficiency was investigated for this deficiency. The deficiency was inherited as an autosomal dominant trait. 4 members of the family had low HC II levels but only the proband had a history of thromboses; however, 2 of 4 affected were only 14 and 23 years old. The deficiency did not affect the anticoagulant action of heparin, with which the patient was treated.