Functional Imaging of Visuospatial Processing in Alzheimer's Disease
Functional Imaging of Visuospatial Processing in Alzheimer's Disease
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DOI：
10.1006/nimg.2002.1271
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发表时间：
2002-11
期刊：
影响因子：
5.7
通讯作者：
D. Prvulovic;D. Hubl;A. Sack;L. Melillo;K. Maurer;L. Frölich;H. Lanfermann;F. Zanella;R. Goebel;D. Linden;D. Linden;T. Dierks
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文献类型：
--
作者：
D. Prvulovic;D. Hubl;A. Sack;L. Melillo;K. Maurer;L. Frölich;H. Lanfermann;F. Zanella;R. Goebel;D. Linden;D. Linden;T. Dierks
众所周知，阿尔茨海默病（AD）会引起多种与神经病理变化密切相关的高级视觉功能障碍。视觉关联区域比初级视觉皮层受到的影响更大。此外，神经心理学和影像学研究的证据表明，在休息或被动视觉刺激期间，枕颞通路受到的影响小于顶叶通路。我们的目标是研究 AD 患者主动视觉空间处理过程中的功能激活模式以及局部脑萎缩对功能激活强度的影响。 14 名 AD 患者和 14 名年龄匹配的对照者在执行角度辨别任务时使用功能磁共振成像 (fMRI) 进行测量。两组均显示出参与角度辨别的重叠网络，包括顶叶上小叶（SPL）、额叶和枕颞（OTC）皮质区域、初级视觉皮层、基底神经节和丘脑。两组之间最显着的差异在于 SPL（对照组活动较多）和 OTC（患者活动较多）。 AD 患者和对照组之间功能激活的差异部分可以通过个体 SPL 萎缩的差异来解释。这些结果表明，轻度至中度 AD 的顶叶功能障碍可以通过腹侧视觉通路的募集来补偿。我们进一步建议，局部脑萎缩应被视为神经退行性疾病功能成像研究中的协变量。
Alzheimer's disease (AD) is known to cause a variety of disturbances of higher visual functions that are closely related to the neuropathological changes. Visual association areas are more affected than primary visual cortex. Additionally, there is evidence from neuropsychological and imaging studies during rest or passive visual stimulation that the occipitotemporal pathway is less affected than the parietal pathway. Our goal was to investigate functional activation patterns during active visuospatial processing in AD patients and the impact of local cerebral atrophy on the strength of functional activation. Fourteen AD patients and fourteen age-matched controls were measured with functional magnetic resonance imaging (fMRI) while they performed an angle discrimination task. Both groups revealed overlapping networks engaged in angle discrimination including the superior parietal lobule (SPL), frontal and occipitotemporal (OTC) cortical regions, primary visual cortex, basal ganglia, and thalamus. The most pronounced differences between the two groups were found in the SPL (more activity in controls) and OTC (more activity in patients). The differences in functional activation between the AD patients and controls were partly explained by the differences in individual SPL atrophy. These results indicate that parietal dysfunction in mild to moderate AD is compensated by recruitment of the ventral visual pathway. We furthermore suggest that local cerebral atrophy should be considered as a covariate in functional imaging studies of neurodegenerative disorders.