MULTIPLE PRIMARY CANCERS OF THE BREAST AND OVARY
MULTIPLE PRIMARY CANCERS OF THE BREAST AND OVARY
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DOI：
10.1038/bjc.1981.247
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发表时间：
1981-01-01
影响因子：
8.8
通讯作者：
WATERHOUSE, JAH
中科院分区：
文献类型：
--
作者：
PRIOR, P;WATERHOUSE, JAH
作为伯明翰和西米德兰兹地区癌症登记处[英国]正在进行的调查的一部分，对乳腺和卵巢的多种原发性癌症进行了调查。分析了1950-1964年间17,756例乳腺癌和3470例卵巢癌登记的人口数据。根据该地区（1960-1962年）的风险人-年和发病率，在45岁以前诊断为乳腺第一原发性肿瘤的患者中，观察到卵巢第二原发性肿瘤的风险增加（O [观察数] = 8; E [预期数] = 1.83; P < 0.001）。在45岁以后确诊的患者中没有发现过量（O = 15; E = 17.06）。在卵巢指数肿瘤患者中，观察到的乳腺第二原发性肿瘤数量与预期数量无显著差异（O = 19; E = 12.95）。互补分析（对两个部位的联合评估）显示，在45岁之前在任何一个部位发生第一原发肿瘤的风险是在另一个部位发生第二原发肿瘤的2.8倍（O = 9; E = 3.21; P < 0.01）。45岁以后没有发现风险增加（O = 32; E = 28.63）。在所有年龄组中，观察到1.3倍的风险（O = 42; E = 31.54; P < 0.05）。绝经前高风险组中发生2种肿瘤的9例患者未发现生育力低下的证据。该结果更符合早期暴露于外部致癌物的病因，而不是异常激素产生的病因。
Multiple primary cancers of the breast and ovary were investigated as part of a survey being undertaken at the Birmingham and West Midlands Regional Cancer Registry [UK]. Population-based data relating to 17,756 registrations for breast and 3470 for ovarian cancer between 1950-1964 were analyzed. On the basis of person-years at risk and incidence rates for the region (1960-1962), an increased risk of a 2nd primary tumor in the ovary was observed in patients diagnosed with a 1st primary in the breast before 45 yr of age (O [observed number] = 8; E [expected number] = 1.83; P < 0.001). No excess was found in patients diagnosed after 45 yr of age (O = 15; E = 17.06). In patients with an index tumor of the ovary, the observed number of 2nd primary tumors of the breast was not significantly different from the expected number (O = 19; E = 12.95). Complementary analysis (a combined assessment for the 2 sites) showed that the development of a 1st primary at either site before 45 yr of age carried a 2.8-fold risk of a 2nd primary tumor at the other site (O = 9; E = 3.21; P < 0.01). After 45 yr of age no increased risk was found (O = 32; E = 28.63). Over all ages a 1.3-fold risk was observed (O = 42; E = 31.54; P < 0.05). No evidence of subfertility was found in the 9 patients in the high-risk premenopausal group who developed the 2 tumors. The results are more consistent with an etiology of early exposure to an external carcinogen than with one of abnormal hormone production.