GENETIC REGULATORY MECHANISMS IN SYNTHESIS OF PROTEINS
GENETIC REGULATORY MECHANISMS IN SYNTHESIS OF PROTEINS
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DOI：
10.1016/s0022-2836(61)80072-7
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发表时间：
1961-01-01
影响因子：
5.6
通讯作者：
MONOD, J
中科院分区：
文献类型：
--
作者：
JACOB, F;MONOD, J
细菌中酶的合成遵循双重遗传控制。所谓的结构基因决定蛋白质的分子组织。其他功能专门化的遗传决定因素，称为调节基因和操纵基因，通过细胞质成分或阻遏物的中介作用来控制蛋白质合成的速率。阻遏蛋白可以被某些特定代谢物灭活（诱导）或激活（抑制）。这种调节系统似乎直接在短寿命中间体或信使基因的合成水平上起作用，该中间体与核糖体相关联，蛋白质合成是在核糖体中发生的。
The synthesis of enzymes in bacteria follows a double genetic control. The so-called structural genes determine the molecular organization of the proteins. Other, functionally specialized, genetic determinants, called regulator and operator genes, control the rate of protein synthesis through the intermediacy of cytoplasmic components or repressors. The repressors can be either inactivated (induction) or activated (repression) by certain specific metabolites. This system of regulation appears to operate directly at the level of the synthesis by the gene of a short-lived intermediate, or messenger, which becomes associated with the ribosomes, where protein synthesis takes place.