Confocal laser endomicroscopy.
Confocal laser endomicroscopy.
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DOI：
10.1016/j.giec.2005.08.010
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发表时间：
2005-10-01
影响因子：
--
通讯作者：
Neurath, Markus F
中科院分区：
文献类型：
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作者：
Kiesslich, Ralf;Goetz, Martin;Neurath, Markus F
开发了一种小型化共聚焦显微镜，可以集成在传统结肠镜的远端。使用这种技术，表示共聚焦显微内镜，在进行中的内窥镜检查过程中的肠粘膜和体内组织学的亚表面分析是可能的，在全分辨率点扫描激光分析。共聚焦显微内镜的诊断范围正在从结直肠癌的筛查和监测扩展到巴雷特食管、幽门螺杆菌相关性胃炎和胃癌。使用共聚焦激光显微内镜观察到的新的详细图像可以对肠道表面及其下方的细胞结构进行独特的观察。本文综述了共焦激光显微内镜的光学和诊断的可能性。
A miniaturized confocal microscope was developed that could be integrated in the distal tip of a conventional colonoscope. With this technique, denoted confocal endomicroscopy, subsurface analysis of the gut mucosa and in-vivo histology during ongoing endoscopy are possible in full resolution by point scanning laser analysis. The diagnostic spectrum of confocal endomicroscopy is expanding from screening and surveillance for colorectal cancer to Barrett's esophagus, Helicobacter pylori-associated gastritis, and gastric cancer. The new detailed images seen with confocal laser endomicroscopy allow a unique look on cellular structures at and below the surface of the gut. This review describes the optical and diagnostic possibilities of confocal laser endomicroscopy.