Onset of dementia is associated with apolipoprotein E epsilon4 in Down's syndrome.
Onset of dementia is associated with apolipoprotein E epsilon4 in Down's syndrome.
复制标题
痴呆症的发作与唐氏综合症中的载脂蛋白 E epsilon4 相关。
DOI：
10.1002/ana.410400518
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Mayeux,R
中科院分区：
文献类型：
--
作者：
Schupf,N;Kapell,D;Lee,JH;Zigman,W;Canto,B;Tycko,B;Mayeux,R
我们研究了82例唐氏综合征(DS)患者的载脂蛋白E(ApoE)基因对痴呆风险的影响。与apoE 3/3基因携带者相比，携带apoE 2/4、3/4和4/4基因携带者患痴呆的几率增加5倍(RR=4.7；95%CI=1.2、17.9)。我们假设，痴呆风险的增加可能是由β-淀粉样蛋白沉积的加剧所介导的。
We examined the influence of apolipoprotein E (apoE) genotype on risk of dementia in 82 adults with Down's syndrome (DS). Compared with those with an apoE 3/3 genotype, the group of adults with DS with apoE 2/4, 3/4, and 4/4 genotypes were 5 times more likely to become demented (RR= 4.7; 95% CI = 1.2, 17.9). We hypothesize that the increased risk of dementia may be mediated by exacerbation of β‐amyloid deposition.