A Model of Chronic Spontaneous Petit Mal‐like Seizures in the Rat: Comparison with Pentylenetetrazol‐Induced Seizures
A Model of Chronic Spontaneous Petit Mal‐like Seizures in the Rat: Comparison with Pentylenetetrazol‐Induced Seizures
复制标题
大鼠慢性自发性小发作样癫痫发作模型：与戊四唑诱发的癫痫发作比较
作者：
C. Marescaux;G. Micheletti;M. Vergnes;Antoine Depaulis;L. Rumbach;Jean
总结：在斯特拉斯堡神经化学中心繁殖群随机选择的100只成年雄性Wistar大鼠中，31只出现自发性、非惊厥性癫痫发作：波形和棘波放电，7-11个克莱斯/秒，200-600 μV，伴有触须和面部及颈部肌肉的行为停止和肌阵挛。戊四氮（PTZ）10和20 mg/kg可使这些自发性癫痫动物的癫痫发作持续时间和次数增加100-150%，并在明显正常的大鼠中引起相同的癫痫发作。丙戊酸钠、地西泮、曲美双酮和乙琥胺可抑制自发性癫痫发作，并以剂量依赖性方式防止PTZ诱导的癫痫发作。卡马西平和苯妥英钠在2例病例中无效或无效。临床、脑电图和药理学观察表明，Wistar大鼠自发性癫痫发作构成了一种有效的小发作失神的生理和药理学模型，与通常的注射致痫药物诱发癫痫发作的模型相比具有优势。
Summary: Of 100 randomly chosen, adult male Wistar rats in the breeding colony at the Centre de Neurochimie, Strasbourg, 31 presented spontaneous, nonconvulsive epileptic seizures: wave‐and‐spike discharges, 7–11 cy‐cles/s, 200–600 μV, accompanied by behavioral arrest and myoclony of the vibrissae and of the facial and cervical muscles. Pentylenetetrazol (PTZ) 10 and 20 mg/kg increased the duration and number of seizures by 100–150% in these spontaneously epileptic animals, and caused identical seizures in apparently normal rats. Sodium valproate, diazepam, trimethadione, and ethosux‐imide suppressed the spontaneous seizures and protected against PTZ‐induced seizures in a dose‐dependent fashion. Carbamazepine and diphenylhydantoin were inefficacious or aggravative in the two cases. The clinical, EEG, and pharmacological observations suggest that the Wistar rats displaying spontaneous seizures constitute a valid physiological and pharmacological model of petit mal absences, presenting advantages compared to the usual models in which seizures are induced byinjected epileptogenic drugs.