Plasmonic magnetic nanostructure for bimodal imaging and photonic-based therapy of cancer cells
Plasmonic magnetic nanostructure for bimodal imaging and photonic-based therapy of cancer cells
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DOI：
10.1002/cbic.200700416
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发表时间：
2007-12-17
期刊：
影响因子：
3.2
通讯作者：
Chung, Bong Hyun
中科院分区：
文献类型：
--
作者：
Lim, Yong Taik;Cho, Mi Young;Chung, Bong Hyun
总之，我们合成了一种具有nir吸收（和散射）光学特性和MRI磁响应部分的新型纳米结构。该纳米复合粒子已被成功地证明可作为双峰成像造影剂以及基于光子的癌细胞治疗剂。从本研究的角度来看，我们期望这些纳米复合颗粒能够使生物学家或医生在术前阶段通过MRI收集诊断性体内成像数据。此外，病理学家可以利用近红外区域的强散射特性，在手术和术后阶段直接分析活检样本，甚至不需要再准备额外的样本。此外，在本研究中开发的多功能纳米结构在与调节药物传递、联合治疗（基因治疗和化疗）和治疗纳米平台相关的更广泛的新应用中具有潜力。
In summary, we synthesized a novel nanostructure that has NIR-absorbing (and scattering) optical characteristics and magnetic-responsive moieties for MRI. The nanocomposite particles were successfully demonstrated for use as bimodal-imaging contrast agents as well as photonic-based therapeutic agents for cancer cells. As a perspective of this research, we expect that these nanocomposite particles would enable biologists or medical doctors to gather diagnostic in vivo imaging data by using MRI at the preoperative stage. In addition, the pathologists can directly analyze biopsy samples during the operative and postoperative stages by using the strong scattering properties in the NIR region, even without any further need to prepare additional samples. Furthermore, the multifunctional nanostructure that was developed in this research has potential in a wider variety of novel applications that are related to modulated drug delivery, combined therapy (gene therapy and chemotherapy), and theranostic nanoplatforms.