What do ratings of cancer-specific distress mean among women at high risk of breast and ovarian cancer?
What do ratings of cancer-specific distress mean among women at high risk of breast and ovarian cancer?
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DOI：
10.1002/ajmg.a.10844
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发表时间：
2003-01-30
影响因子：
2
通讯作者：
Armstrong, K
中科院分区：
文献类型：
--
作者：
Coyne, JC;Kruus, L;Armstrong, K
从遗传性癌症登记处招募的妇女提供了与高风险状态和基因测试的不同方面相关的痛苦等级，并完成了一般心理痛苦、情感和社会健康以及角色功能的测量。总的来说，高风险状态被认为比接受基因检测更令人痛苦。没有个人癌症病史的女性认为，与检测结果呈阳性相关的痛苦程度要高于与高风险状况相关的痛苦程度。相比之下，与阳性检测结果相关的痛苦程度与与个人有癌症病史的高风险状态相关的痛苦程度没有显著差异。此外，有个人癌症病史的女性还预计，如果她们有一个与癌症风险增加相关的基因改变，那么就不会像她们被诊断出癌症那样痛苦。癌症相关压力评分最高的女性不太倾向于接受检测，但总体上不会更痛苦或不适应。需要解释心理困扰和压力的基因检测高危妇女相对于相关的比较数据进行了讨论。(C) 2002 Wiley-Liss, Inc。
Women recruited from a hereditary cancer registry provided ratings of distress associated with different aspects of high-risk status and genetic testing and completed measures of general psychological distress, emotional and social health, and role functioning. Overall, high-risk status was rated as more distressing than undergoing genetic testing. Women without a personal history of cancer rated the level of distress associated with a positive test result to be greater than that associated with high-risk status. In contrast, level of distress associated with a positive test result was not significantly different from that associated with high-risk status for women with a personal history of cancer. Furthermore, women with a personal cancer history also anticipated that if they had an altered gene associated with increased risk of cancer, it would be less distressing than their diagnosis of cancer had been. Women with the highest ratings of cancer-related stress were less inclined to obtain testing, but were not more generally distressed or maladjusted. The need to interpret psychological distress and the stressfulness of genetic testing among high-risk women with respect to relevant comparison data is discussed. (C) 2002 Wiley-Liss, Inc.