CD8(+)CD122(+) T-Cells: A Newly Emerging Regulator with Central Memory Cell Phenotypes.
CD8(+)CD122(+) T-Cells: A Newly Emerging Regulator with Central Memory Cell Phenotypes.
复制标题
CD8( )CD122( ) T 细胞：具有中央记忆细胞表型的新兴调节因子
DOI：
10.3389/fimmu.2015.00494
复制
发表时间：
2015
影响因子：
7.3
通讯作者：
Dai Z
中科院分区：
文献类型：
--
作者：
Liu J;Chen D;Nie GD;Dai Z
CD8 + CD122 + T细胞传统上被描述为抗原特异性记忆T细胞，与初始T细胞相比，它们对先前遇到的抗原反应更迅速、更强烈。然而，越来越多的证据表明，小鼠CD8 + CD122 + T细胞呈现中枢记忆表型（CD44高表达CD62L高表达），调节T细胞内稳态，并通过抑制自身免疫和同种免疫反应发挥调节性T细胞（Treg）的作用。重要的是，天然存在的小鼠CD8 + CD122 + Tregs在免疫抑制方面比CD4 + CD25 + Tregs更强。它们似乎以一种非抗原特异性的方式发挥作用。人CD8 + CXCR3 + T细胞相当于小鼠CD8 + CD122 + Tregs，也呈现中枢记忆表型。在这篇小型综述文章中，我们将总结它们在表型、稳态扩增、抗原特异性、在抑制同种免疫和自身免疫反应中的作用以及其抑制功能潜在机制方面的最新进展。
CD8+CD122+ T-cells have been traditionally described as antigen-specific memory T-cells that respond to previously encountered antigens more quickly and vigorously than their naïve counterparts. However, mounting evidence has demonstrated that murine CD8+CD122+ T-cells exhibit a central memory phenotype (CD44highCD62Lhigh), regulate T cell homeostasis, and act as regulatory T-cells (Treg) by suppressing both autoimmune and alloimmune responses. Importantly, naturally occurring murine CD8+CD122+ Tregs are more potent in immunosuppression than their CD4+CD25+ counterparts. They appear to be acting in an antigen-non-specific manner. Human CD8+CXCR3+ T-cells are the equivalent of murine CD8+CD122+ Tregs and also exhibit central memory phenotypes. In this mini-review article, we will summarize recent progresses in their phenotypes, homeostatic expansion, antigen-specificity, roles in the suppression of alloimmune and autoimmune responses, and the mechanisms underlying their inhibitory function.