Processing and analysis of in vivo high-resolution MR images of trabecular bone for longitudinal studies: Reproducibility of structural measures and micro-finite element analysis derived mechanical properties
Processing and analysis of in vivo high-resolution MR images of trabecular bone for longitudinal studies: Reproducibility of structural measures and micro-finite element analysis derived mechanical properties
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DOI：
10.1007/s001980200027
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发表时间：
2002-01-01
影响因子：
4
通讯作者：
Majumdar, S
中科院分区：
文献类型：
--
作者：
Newitt, DC;van Rietbergen, B;Majumdar, S
作者开发了一个系统，用于从高分辨率MR图像表征骨小梁结构。其主要特点是自动线圈不均匀性校正、骨小梁区域分割、序列图像配准、骨/骨髓二值化和结构计算步骤。该系统解决了以前分析中固有的效率和操作员间和操作员内变异性问题。该系统进行了评估的8名志愿者的重复扫描的二维（2D）表观结构计算和三维（3D）的机械计算，使用微观有限元分析。基于线圈灵敏度的先验知识和高分辨率图像的低通滤波的线圈校正方法进行比较，发现执行类似。图像对齐被发现会引起一些结构参数的微小但显著的变化。总体而言，与之前的手动方法相比，自动化系统的培训操作员时间减少了3倍。对于大多数参数，再现性取决于图像质量。对于7名图像质量良好的受试者，2D结构参数的再现性为24%，而3D机械参数的变化为4- 9%，标准化变异系数分别为15-34%和20-38%。
The authors have developed a system for the characterization of trabecular bone structure from high-resolution MR images. It features largely automated coil inhomogeneity correction, trabecular bone region segmentation, serial image registration, bone/marrow binarization, and structural calculation steps. The system addresses problems of efficiency and inter- and intraoperator variability inherent in previous analyses. The system is evaluated on repetitive scans of 8 volunteers for both two-dimensional (2D) apparent structure calculations and three-dimensional (3D) mechanical calculations using micro-finite element analysis. Coil correction methods based on a priori knowledge of the coil sensitivity and on low-pass filtering of the high-resolution mages are compared and found to perform similarly. Image alignment is found to cause small but significant changes in some structural parameters. Overall the automated system provides on the order of a 3-fold decrease in trained operator time over previous manual methods. Reproducibility is found to be dependent on image quality for most parameters. For 7 subjects with good image quality, reproducibility of 24% is found for 2D structural parameters, while 3D mechanical parameters vary by 4-9%, with percent standardized coefficients of variation in the ranges of 15-34% and 20-38% respectively.