Differential behavioral state-dependence in the burst properties of CA3 and CA1 neurons.
Differential behavioral state-dependence in the burst properties of CA3 and CA1 neurons.
复制标题
CA3 和 CA1 神经元突发特性的不同行为状态依赖性。
DOI：
10.1016/j.neuroscience.2006.05.052
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发表时间：
2006
期刊：
影响因子：
3.3
通讯作者：
Markus,EJ
中科院分区：
文献类型：
--
作者：
TroppSneider,J;Chrobak,JJ;Quirk,MC;Oler,JA;Markus,EJ
快速高频动作电位的短暂爆发是CA3和CA1锥体神经元的特征。了解决定爆发和单次发放的因素对感觉表征、突触可塑性和癫痫发生具有重要意义。各种模型表明不同的功能作用的突发放电，并为特定的特点，突发在神经编码。然而，很少有体内数据表明，如何经常和在什么条件下，CA3和CA1实际上表现出爆发和单尖峰放电。本研究探讨了不同的行为状态（清醒不动和迷宫运行）在大鼠的CA3和CA1神经元的爆发性放电和单尖峰。在CA3和CA1的棘波爆发占所有棘波事件的不到20%。与CA1神经元相比，CA3神经元表现出更多的峰电位、更高的峰电位频率、更大的峰电位幅度和更大的峰电位幅度衰减。本研究的一个主要发现是，行为状态影响CA1神经元的爆发倾向，而CA3的爆发倾向则不受影响。CA1区神经元在迷宫实验中的爆发次数少于清醒不动组。相反，CA3神经元的爆发放电没有差异。在这两个亚区的神经元表现出较小的尖峰幅度，更少的尖峰每次爆发，更长的尖峰间期和更大的尖峰幅度衰减在一个突发在清醒不动的迷宫运行相比。这些研究结果表明，CA1网络比CA3网络受到更大的行为状态依赖调节。目前的研究结果应通知CA3和CA1功能的理论和计算模型。
Brief bursts of fast high-frequency action potentials are a signature characteristic of CA3 and CA1 pyramidal neurons. Understanding the factors determining burst and single spiking is potentially significant for sensory representation, synaptic plasticity and epileptogenesis. A variety of models suggest distinct functional roles for burst discharge, and for specific characteristics of the burst in neural coding. However, little in vivo data demonstrate how often and under what conditions CA3 and CA1 actually exhibit burst and single spike discharges. The present study examined burst discharge and single spiking of CA3 and CA1 neurons across distinct behavioral states (awake-immobility and maze-running) in rats. In both CA3 and CA1 spike bursts accounted for less than 20% of all spike events. CA3 neurons exhibited more spikes per burst, greater spike frequency, larger amplitude spikes and more spike amplitude attenuation than CA1 neurons. A major finding of the present study is that the propensity of CA1 neurons to burst was affected by behavioral state, while the propensity of CA3 to burst was not. CA1 neurons exhibited fewer bursts during maze running compared with awake-immobility. In contrast, there were no differences in burst discharge of CA3 neurons. Neurons in both subregions exhibited smaller spike amplitude, fewer spikes per burst, longer inter-spike intervals and greater spike amplitude attenuation within a burst during awake-immobility compared with maze running. These findings demonstrate that the CA1 network is under greater behavioral state-dependent regulation than CA3. The present findings should inform both theoretic and computational models of CA3 and CA1 function.