Increased Cerebellar Functional Connectivity With the Default-Mode Network in Unaffected Siblings of Schizophrenia Patients at Rest
Increased Cerebellar Functional Connectivity With the Default-Mode Network in Unaffected Siblings of Schizophrenia Patients at Rest
复制标题
精神分裂症患者未受影响的兄弟姐妹在休息时小脑与默认模式网络的功能连接增加
DOI：
10.1093/schbul/sbv062
复制
发表时间：
2015-11-01
影响因子：
6.6
通讯作者：
Zhao, Jingping
中科院分区：
文献类型：
--
作者：
Guo, Wenbin;Liu, Feng;Zhao, Jingping
默认模式网络（DMN）在精神分裂症的神经生物学中至关重要，而小脑参与了DMN等高阶认知网络。然而，在精神分裂症患者未受影响的同胞中，小脑对DMN异常的具体贡献仍不清楚。46名精神分裂症患者和46名健康对照的未受影响的兄弟姐妹被招募进行静息状态扫描。使用功能连接性（FC）方法分析图像。与对照组相比，同胞显示左侧小腿I与左侧上级内侧前额叶皮质（MPFC）之间以及小叶IX与双侧MPFC（眶部）和右侧上级MPFC之间的FC显著增加。相对于对照组，在同胞中未观察到FC显著降低。在49例首次发病的精神分裂症患者中重复分析，结果显示，与对照组相比，兄弟姐妹和患者在左小腿I和左上级MPFC之间以及小叶IX和左MPFC（眼眶部分）之间共享增加的FC。这些研究结果表明，小脑DMN连接的增加出现早于疾病发作，这突出了小脑的DMN在未受影响的兄弟姐妹的改变的贡献。患者和兄弟姐妹之间共享的小脑-DMN连接性增加可用作精神分裂症的候选内表型。
The default-mode network (DMN) is vital in the neurobiology of schizophrenia, and the cerebellum participates in the high-order cognitive network such as the DMN. However, the specific contribution of the cerebellum to the DMN abnormalities remains unclear in unaffected siblings of schizophrenia patients. Forty-six unaffected siblings of schizophrenia patients and 46 healthy controls were recruited for a resting-state scan. The images were analyzed using the functional connectivity (FC) method. The siblings showed significantly increased FCs between the left Crus I and the left superior medial prefrontal cortex (MPFC), as well as between the lobule IX and the bilateral MPFC (orbital part) and right superior MPFC compared with the controls. No significantly decreased FC was observed in the siblings relative to the controls. The analyses were replicated in 49 first-episode, drug-naive patients with schizophrenia, and the results showed that the siblings and the patients shared increased FCs between the left Crus I and the left superior MPFC, as well as between the lobule IX and the left MPFC (orbital part) compared with the controls. These findings suggest that increased cerebellar-DMN connectivities emerge earlier than illness onset, which highlight the contribution of the cerebellum to the DMN alterations in unaffected siblings. The shared increased cerebellar-DMN connectivities between the patients and the siblings may be used as candidate endophenotypes for schizophrenia.