Pd/NHC-catalyzed cross-coupling reactions of nitroarenes
Pd/NHC-catalyzed cross-coupling reactions of nitroarenes
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DOI：
10.1039/c9cc05055h
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发表时间：
2019-08-14
影响因子：
4.9
通讯作者：
Nakao, Yoshiaki
中科院分区：
文献类型：
--
作者：
Kashihara, Myuto;Zhong, Rong-Lin;Nakao, Yoshiaki
N-杂环卡宾（NHC）配体有效的交叉偶联硝基芳烃进行了鉴定。与采用BrettPhos作为膦配体的先前系统相比，NHC配体结构的合理设计能够显著降低催化剂负载。比较这些配体的实验和理论研究为新开发的NHC配体的高活性提供了一些见解。
N-Heterocyclic carbene (NHC) ligands effective for the cross-coupling of nitroarenes were identified. A rational design of the NHC ligand structures enabled significant reduction of catalyst loadings compared with the previous system employing BrettPhos as a phosphine ligand. Experimental and theoretical studies to compare these ligands gave some insights into high activity of the newly developed NHC ligands.