Attempts to prevent disuse osteoporosis by treatment with calcitonin, longitudinal compression and supplementary calcium and phosphate.
Attempts to prevent disuse osteoporosis by treatment with calcitonin, longitudinal compression and supplementary calcium and phosphate.
复制标题
尝试通过降钙素治疗、纵向压迫以及补充钙和磷酸盐来预防废用性骨质疏松症。
DOI：
10.1210/jcem-36-5-845
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发表时间：
1973
期刊：
影响因子：
--
通讯作者：
S. Hulley
中科院分区：
文献类型：
--
作者：
D. Hantman;J. Vogel;C. L. Donaldson;R. Friedman;R. Goldsmith;S. Hulley
在19周的连续卧床休息期间，对6名健康男性进行了研究，并测试了3种治疗方案在预防骨矿物质损失方面的有效性：1.合成鲑鱼降钙素（每日100 MRC U）不能预防在未治疗的卧床休息期间观察到的负钙磷平衡。两名受试者之一的尿钙和羟脯氨酸排泄量增加异常大。2.通过连接到特殊套装上的弹簧在纵向轴上施加间歇性压缩;每天4小时，每分钟施加45次等于体重80%的力。负矿物质平衡没有受到这种方案的实质性影响。3.给予钙和磷酸盐补充剂，将每日钙摄入量从1.0增加到1.8或2.3 g，磷从1.7增加到3.0 g。钙平衡显着低于负比对照组的5例中的4例;磷平衡显示出类似的模式。4.联合管理…
Six healthy men were studied during 19 weeks of continuous bed rest and 3 treatment regimens were tested for their effectiveness in preventing bone mineral loss: 1. Synthetic salmon calcitonin (100 MRC U daily) did not prevent the negative calcium and phosphorus balances which are observed during untreated bed rest. The increase in urinary calcium and hydroxyproline excretion was unusually large in one of the two subjects. 2. Intermittent compression in the longitudinal axis was applied by springs attached to a special suit; a force equal to 80% of body wt was applied 45 times per min for 4 hr daily. The negative mineral balances were not substantially affected by this regimen. 3. Calcium and phosphate supplements were administered, increasing daily intake of calcium from 1.0 to 1.8 or 2.3 g, and that of phosphorus from 1.7 to 3.0 g. Calcium balances were significantly less negative than those of control subjects in four of five cases; phophorus balances showed similar patterns. 4. Combined administration...