Ti nanorod arrays with a medium density significantly promote osteogenesis and osteointegration.
Ti nanorod arrays with a medium density significantly promote osteogenesis and osteointegration.
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DOI：
10.1038/srep19047
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发表时间：
2016-01-08
影响因子：
4.6
通讯作者：
Mao C
中科院分区：
文献类型：
--
作者：
Ning C;Wang S;Zhu Y;Zhong M;Lin X;Zhang Y;Tan G;Li M;Yin Z;Yu P;Wang X;Li Y;He T;Chen W;Wang Y;Mao C
钛种植体是骨修复的良好候选者。然而，如何促进其表面的骨形成及其与周围组织的完美结合仍然是一个挑战。为了克服这一挑战，我们建议在其表面形成钛纳米棒，以促进种植体周围的新骨形成。本文采用阳极氧化的方法在纯钛表面制备了不同密度的钛纳米棒阵列。观察TNR浓度对MC3T3-E1前成骨细胞蛋白质吸附、黏附、增殖和成骨分化的影响。将TnRs植入兔骨缺损处，观察其在促进种植体-骨界面骨形成和骨整合方面的应用。中等密度的TnRs在促进蛋白质从周围介质中吸附的能力最强，从而有效地促进了体外成骨分化和体内的骨整合。我们的工作表明，在传统的钛种植体表面生长中等密度的TnRs是一种有效和简便的促进骨形成和骨整合的骨修复方法。
Ti implants are good candidates in bone repair. However, how to promote bone formation on their surface and their consequent perfect integration with the surrounding tissue is still a challenge. To overcome such challenge, we propose to form Ti nanorods on their surface to promote the new bone formation around the implants. Here Ti nanorod arrays (TNrs) with different densities were produced on pure Ti surfaces using an anodizing method. The influence of TNr density on the protein adsorption as well as on the adhesion, proliferation, and osteogenic differentiation of MC3T3-E1 pre-osteoblastic cells were assessed. The TNrs were also implanted into the bone defects in rabbits to test their application in promoting bone formation and osteointegration at the implant-bone interface. TNrs with the medium density were found to show the best capability in promoting the protein adsorption from surrounding medium, which in turn efficiently enhanced osteogenic differentiation in vitro and osteointegration in vivo. Our work suggests that growing TNrs with a medium density on the surface of traditional Ti implants is an efficient and facile method for promoting bone formation and osteointegration in bone repair.