Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management
Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management
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DOI：
10.1016/j.ejim.2015.04.022
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发表时间：
2015-09-01
影响因子：
8
通讯作者：
Guillevin, Loic
中科院分区：
文献类型：
--
作者：
Groh, Matthieu;Pagnoux, Christian;Guillevin, Loic
目的：为制定诊断和治疗嗜酸性肉芽肿伴多血管炎（Churg-Strauss综合征）（EGPA）的疾病特异性建议，EGPA共识工作组专家包括来自5个欧洲国家和美国的8名肺病学家、6名内科医生、4名风湿病学家、3名肾病学家、1名病理学家和1名过敏症专家。2名成员采用经修改的德尔菲程序拟订了一份40个问题的清单，并在会前发给所有与会者。同时，对根据公认标准指定证据等级的出版物进行了广泛的文献检索。草案的建议分发给所有成员进行审查，直到最后的共识达成agreed.Results：二十二个建议，关于诊断，初步评估，治疗和监测的EGPA患者成立。EGPA，抗中性粒细胞胞质抗体相关的血管炎，嗜酸性粒细胞增多综合征和嗜酸性粒细胞性哮喘支持这些recommendations.Discussion的相关出版信息：这些建议的目的是给医生的工具，有效和个别管理的EGPA患者，并提供指导，为进一步有针对性的研究。(C)2015年欧洲内科联盟。Elsevier B.V.出版，保留所有权利。
Objective: To develop disease-specific recommendations for the diagnosis and management of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) (EGPA).Methods: The EGPA Consensus Task Force experts comprised 8 pulmonologists, 6 internists, 4 rheumatologists, 3 nephrologists, 1 pathologist and 1 allergist from 5 European countries and the USA. Using a modified Delphi process, a list of 40 questions was elaborated by 2 members and sent to all participants prior to the meeting. Concurrently, an extensive literature search was undertaken with publications assigned with a level of evidence according to accepted criteria. Drafts of the recommendations were circulated for review to all members until final consensus was reached.Results: Twenty-two recommendations concerning the diagnosis, initial evaluation, treatment and monitoring of EGPA patients were established. The relevant published information on EGPA, antineutrophil-cytoplasm antibody-associated vasculitides, hypereosinophilic syndromes and eosinophilic asthma supporting these recommendations was also reviewed.Discussion: These recommendations aim to give physicians tools for effective and individual management of EGPA patients, and to provide guidance for further targeted research. (C) 2015 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.