A Centromere-Signaling Network Underlies the Coordination among Mitotic Events.
A Centromere-Signaling Network Underlies the Coordination among Mitotic Events.
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DOI：
10.1016/j.tibs.2015.11.002
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发表时间：
2016-02
影响因子：
13.8
通讯作者：
Stukenberg PT
中科院分区：
文献类型：
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作者：
Trivedi P;Stukenberg PT
越来越多的证据表明，纺锤体检查点、着丝点微管附着和姐妹染色单体内聚的调节因子是一个相互连接的有丝分裂调节回路的一部分，该回路具有两个正反馈回路，染色体乘客复合体（CPC）位于其中心。如果这是真的，这个概念上的突破需要整合到有丝分裂的模型中。在这篇综述中，我们描述了这个回路，并指出双反馈回路如何能够为一些有丝分裂过程的自组织和有丝分裂纺锤体上每条染色体的自主性提供见解。我们还将为有丝分裂事件如何通过这个回路进行协调提供工作模型。
There is increasing evidence that regulators of the spindle checkpoint, kinetochore microtubule attachments and sister chromatid cohesion are part of an interconnected mitotic regulatory circuit with two positive feedback loops and the Chromosome Passenger Complex (CPC) at its center. If true, this conceptual breakthrough needs to be integrated into models of mitosis. In this review, we describe this circuit and point out how the double feedback loops could provide insights into the self-organization of some mitotic processes and the autonomy of every chromosome on the mitotic spindle. We will also provide working models for how mitotic events may be coordinated by this circuit.
DOI：
10.1016/j.cub.2010.05.017
发表时间：
2010-06-22
期刊：
Current biology : CB
影响因子：
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作者：
Stukenberg PT;Foltz DR
通讯作者：
Foltz DR