Comparing the benefits of diet and exercise in the treatment of dyslipidemia
Comparing the benefits of diet and exercise in the treatment of dyslipidemia
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DOI：
10.1006/pmed.2002.1052
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发表时间：
2002-07-01
影响因子：
5.1
通讯作者：
Grover, SA
中科院分区：
文献类型：
--
作者：
Lalonde, L;Gray-Donald, K;Grover, SA
背景生活方式的改变被提倡作为血脂异常的一线治疗。然而，很少有研究直接比较了饮食和运动的各种组合。在一项随机对照的试点研究中，我们比较了标准的生活方式建议（NCEP第一步饮食与定期运动）和更强烈的干预措施，包括NCEP第一步饮食与监督有氧运动计划和第二步饮食与监督有氧运动计划。我们测量了基线和3个月后的危险因素、饮食摄入量、跑步时间和健康相关生活质量。在198例合格受试者中，47例（24%）愿意参加，41例完成研究。标准生活方式建议没有观察到显着变化。相比之下，更强烈干预的参与者体重减轻（-1.7至-3.7公斤），总胆固醇（-4%至-6%），低密度脂蛋白胆固醇（-6%）和收缩压（-7.3至-8.8 mmHg）降低。参加锻炼计划的人显著提高了他们的运动能力（1.6至1.9 AMTS）。总的来说，体重每减少10%，低密度脂蛋白胆固醇就减少7.6%。标准的生活方式建议对血脂水平几乎没有影响，但更强烈的生活方式干预可能对改善血脂，其他危险因素和生活质量有效。(C)2002年美国健康基金会和爱思唯尔科学（美国）。
Background. Lifestyle changes are advocated as a first line of treatment for dyslipidemia. However, few studies have directly compared various combinations of diets and exercise.Methods. In a randomized controlled pilot study, we compared the standard lifestyle recommendations (NCEP step I diet with regular exercise) and more intense interventions including the NCEP step I diet with a supervised aerobic exercise program and the step II diet with and without a supervised aerobic exercise program. We measured risk factors, dietary intake, time on treadmill, and health-related quality of life at baseline and after 3 months.Results. Out of 198 eligible subjects, 47 (24%) were willing to participate and 41 completed the study. No significant change were observed with standard lifestyle recommendations. In contrast, participants in the more intense interventions lost weight (-1.7 to -3.7 kg) and reduced their total cholesterol (-4% to -6%), low-density lipoprotein cholesterol (-6%), and systolic blood pressure (-7.3 to -8.8 mmHg). Participants in the exercise program significantly increased their exercise capacity (1.6 to 1.9 AMTS). Overall, each 10% reduction in body weight was associated with a 7.6% reduction in low-density lipoprotein cholesterol.Conclusion. Standard lifestyle recommendations had little effect on blood lipid levels but more intense lifestyle interventions may be effective at improving blood lipids, other risk factors, and quality of life. (C) 2002 American Health Foundation and Elsevier Science (USA).