Expression of α4β7 integrin defines a distinct pathway of lymphoid progenitors committed to T cells, fetal intestinal lymphotoxin producer, NK, and dendritic cells
Expression of α4β7 integrin defines a distinct pathway of lymphoid progenitors committed to T cells, fetal intestinal lymphotoxin producer, NK, and dendritic cells
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DOI：
10.4049/jimmunol.167.5.2511
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发表时间：
2001-09-01
影响因子：
4.4
通讯作者：
Nishikawa, S
中科院分区：
文献类型：
--
作者：
Yoshida, H;Kawamoto, H;Nishikawa, S
在胚胎发生过程中，Peyer’s patch anlagen是由IL-7R α刺激后产生淋巴素(LT) α (1) β(2)的细胞群诱导产生的。在这项研究中，我们发现产生lt的细胞定位于胚胎肠的IL-7R α(+)和整合素α (4) β (7) (α (4) β(7))（+）群体中。谱系对胎儿肝脏中LT产生者表型的承诺与α (4) β(7)的表达一致。在α (4) β(7)表达之前，IL-7R α(+)群体产生B细胞的潜能丧失。然而，T细胞和LT产生细胞的祖细胞存在于IL-7R α (+) α (4) β(+)(7)细胞中，但在随后的分化过程中，产生T细胞的潜力就丧失了。这个IL-7R α (+) α (4) β(+)(7)种群迁移到肠道，在那里诱导Peyer's斑块原。当受到IL-15或IL-3和TNF的刺激时，肠道IL-7R α (+) α (4) β(+)(7)群体可以分化为完全胜任的NK1.1(+) NK细胞或CD11c(+) apc。α(4)和β(7)的表达在两个谱系的分化过程中丢失；在NK1.1（+）细胞分化过程中，IL-7R α表达缺失。一个新发现的谱系（-）IL-7R α (+)c-Kit(+) α (4) β(+)(7)群体在胎儿肝脏中致力于T、NK、树突状和胎儿肠道LT产生谱系，后者是NK细胞和树突状细胞分化的中间阶段。
During embryogenesis, the Peyer's patch anlagen are induced by a cell population that produces lymphotoxin (LT) alpha (1)beta (2) following stimulation of IL-7R alpha. In this study, we show that the LT-producing cell is localized within the IL-7R alpha (+) and integrin alpha (4)beta (7) (alpha (4)beta (7))(+) population in the embryonic intestine. Lineage commitment to the LT producer phenotype in the fetal liver coincides with expression of alpha (4)beta (7). Before expression of alpha (4)beta (7), the potential of IL-7R alpha (+) population to generate B cells is lost. However, the progenitors for T cells and LT producer cells reside in the IL-7R alpha (+)alpha (4)beta (+)(7) cells, but during subsequent differentiation, the potential to give rise to T cells is lost. This IL-7R alpha (+)alpha (4)beta (+)(7) population migrates to the intestine, where it induces the Peyer's patch anlagen. When stimulated with IL-15 or IL-3 and TNF, the intestinal IL-7R alpha (+)alpha (4)beta (+)(7) population can differentiate into fully competent NK1.1(+) NK cells or CD11c(+) APCs. Expression of alpha (4)beta (7) is lost during differentiation of both lineages; IL-7R alpha expression is lost during NK1.1(+) cells differentiation. A newly discovered lineage(-)IL-7R alpha (+)c-Kit(+)alpha (4)beta (+)(7) population in the fetal liver is committed to T, NK, dendritic, and fetal intestinal LT producer lineage, the latter being an intermediate stage during differentiation of NK and dendritic cells.