THREAT OF UNEMPLOYMENT AND CARDIOVASCULAR RISK-FACTORS - LONGITUDINAL-STUDY OF QUALITY OF SLEEP AND SERUM-CHOLESTEROL CONCENTRATIONS IN MEN THREATENED WITH REDUNDANCY
THREAT OF UNEMPLOYMENT AND CARDIOVASCULAR RISK-FACTORS - LONGITUDINAL-STUDY OF QUALITY OF SLEEP AND SERUM-CHOLESTEROL CONCENTRATIONS IN MEN THREATENED WITH REDUNDANCY
复制标题
DOI：
10.1136/bmj.301.6750.461
复制
发表时间：
1990-09-08
影响因子：
105.7
通讯作者：
THEORELL, T
中科院分区：
文献类型：
--
作者：
MATTIASSON, I;LINDGARDE, F;THEORELL, T
目的：探讨失业威胁对心血管疾病危险因素的影响。设计图：对一组中年造船厂工人进行了平均6.2年（SD 1.9）的纵向研究，并在同一时期观察了一组对照组。第一次调查是在船厂经济相对稳定的时期进行的，第二次调查是在船厂关闭的阶段进行的。背景：瑞典马尔莫的一个年龄队列健康筛查项目。 参与者：715名男性造船厂工人和261名年龄匹配的男性对照。主要结局指标：通过问卷调查评估与心血管疾病风险相关的19个变量以及心理变量、饮酒、吸烟和饮食习惯的变化。结果如下：造船厂工人血清胆固醇浓度较对照组升高（平均0.25（SD 0.68）mmol/l v0.08（0.66）mmol/l），血清钙浓度较对照组降低（-0.06（0.10）mmol/l v-0.08（0.09）mmol/l）。睡眠障碍评分与血清胆固醇浓度变化之间存在相关性。在整个系列中，面临失业威胁的男性（437/976; 44.8%）血清胆固醇浓度的增加幅度大于未面临失业威胁的男性。在逐步回归分析中，血清胆固醇浓度的变化与血红蛋白浓度、体重、血清甘油三酯和钙浓度的变化相关。胆固醇浓度的变化与血压的变化呈正相关，表明血清胆固醇浓度升高的男性总体风险状况恶化。结论：失业风险增加了中年男性的血清胆固醇浓度，这种增加在睡眠障碍者中更为明显。血清胆固醇的增加与其他已确定的心血管疾病危险因素的变化有关。这些发现可能部分解释了失业者和睡眠障碍者因心血管疾病导致的过高死亡率。
Objective: To asess whether the threat of unemployment affects risk factors for cardiovascular disease. Design: Longitudinal study of a cohort of middle aged shipyard workers followed up for a mean of 6.2 (SD 1.9) years and a group of controls observed for the same period. The first investigation took place during a period of relative economic stability for the shipyard and the second during the phase of its closure. Setting: An age cohort health screening programme in Malmo, Sweden. Participants: 715 Male shipyard workers and 261 age matched male controls. Main outcome measures: Changes in 19 variables related to the risk of cardiovascular disease, and psychological variables, alcohol consumption, smoking, and dietary habits as assessed by questionnaire. Results: Serum cholesterol concentratrions increased more (mean 0.25 (SD 0.68) mmol/l v 0.08 (0.66) mmol/l) and serum calcium concentrations decreased less (-0.06 (0.10) mmol/l v -0.08 (0.09) mmol/l) in the shipyard workers than in the controls. A correlation was found between scores for sleep disturbance and changes in serum cholesterol concentration. In the whole series there was a greater increase in serum cholesterol concentrations among men threatened with unemployment (437/976; 44.8%) than among those who were not. In stepwise regression analysis the change in serum cholesterol concentration was correlated with changes in haemoglobin concentration, body weight, and serum triglyceride and calcium concentrations. A positive correlation was found between change in cholesterol concentration and change in blood pressure, indicating that the overall risk profile had worsened among men with increased serum cholesterol concentrations. Conclusions: Risk of unemployment increases the serum cholesterol concentration in middle aged men, the increase being more pronounced in those with sleep disturbance. The increase in serum cholesterol is related to change in other established risk factors for cardiovascular disease. These findings might partly explain the excessive mortality due to cardiovascular disease recorded among the unemployed and people with sleep disturbance.