Cell-pattern disordering during convergent extension in Drosophila
Cell-pattern disordering during convergent extension in Drosophila
复制标题
果蝇会聚延伸过程中的细胞模式紊乱
DOI：
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
R. Zallen
中科院分区：
文献类型：
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作者：
J. Zallen;R. Zallen
会聚延伸是细胞重排过程，通过该过程，发育中的胚胎伸长以建立头到尾的体轴。在早期的果蝇胚胎中，这个过程发生在一个细胞厚的上皮层中。使用共聚焦显微镜，图像收集的二维细胞图案在四个阶段，在收敛扩展在野生型胚胎和在一个阶段，在两个类的突变体胚胎。根据统计分布p（n）（n侧细胞的出现频率）分析细胞拓扑结构。对于野生型胚胎，结果表明在会聚延伸过程中进行性细胞模式紊乱。p（n）的二阶矩（方差）增加三倍至1.1，而p（6）处的峰值从0.65下降至0.38。四重顶点（四条边相交）的比例从2%增加到8%。界面取向的定量分析表明，在收敛扩展过程中，六角边缘取向序的初始度基本消失。两个突变体的细胞模式紊乱的程度类似于野生型的不同阶段，并与轴伸长的程度相关。
Convergent extension is the cell-rearrangement process by which a developing embryo elongates to establish the head-to-tail body axis. In the early Drosophila embryo, this process occurs within a one-cell-thick epithelial layer. Using confocal microscopy, images were collected of the two-dimensional cell pattern at four stages during convergent extension in wild-type embryos and at one stage in two classes of mutant embryos. The cellular topology was analysed in terms of the statistical distribution p(n), the frequency of occurrence of n-sided cells. For wild-type embryos, the results demonstrate progressive cell-pattern disordering during convergent extension. The second moment (variance) of p(n) triples to 1.1 while the peak at p(6) drops from 0.65 to 0.38. The fraction of fourfold vertices (four edges meeting) increases from 2% to 8%. Quantitative analysis of interface orientations reveals that the initial degree of hexatic edge-orientational order essentially disappears during the course of convergent extension. The degree of cell-pattern disordering in the two mutants resembles distinct stages in the wild type and correlates with the extent of axis elongation.
果蝇种带延伸过程中的细胞嵌入及其对规则分割基因的调节。
DOI：
10.1242/dev.120.4.827
发表时间：
1994
期刊：
Development (Cambridge, England)
影响因子：
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作者：
Irvine,KD;Wieschaus,E
通讯作者：
Wieschaus,E