Endocrine aspects of organelle stress—cell non-autonomous signaling of mitochondria and the ER.
Endocrine aspects of organelle stress—cell non-autonomous signaling of mitochondria and the ER.
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DOI：
10.1016/j.ceb.2015.01.006
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发表时间：
2015-04
影响因子：
7.5
通讯作者：
R. Schinzel;A. Dillin
中科院分区：
文献类型：
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作者：
R. Schinzel;A. Dillin
生物体必须应对不可预测的动态环境。对于任何生物来说，通过缓冲对细胞稳态的影响来应对这些变化是至关重要的。不能恰当地应对压力会对健康和生存造成严重后果。真核细胞具有几种细胞器特异性应激反应来应对这一挑战。除了在抗逆性中发挥核心作用外，这些途径也被证明在蛋白质组维持、发育和寿命的调节中发挥重要作用。有趣的是，许多这些效应似乎仅由一小部分细胞控制，这意味着以细胞非自主的方式进行系统调节。了解这种跨组织应激沟通的本质、机制和影响，将对了解疾病病因和制定治疗策略至关重要。
Organisms have to cope with an unpredictable and dynamic environment. It is crucial for any living being to respond to these changes by buffering the effects on cellular homeostasis. Failure to appropriately respond to stress can have severe consequences for health and survival. Eukaryotic cells possess several organelle-specific stress responses to cope with this challenge. Besides their central role in stress resistance, these pathways have also been shown to be important in the regulation of proteome maintenance, development and longevity. Intriguingly, many of these effects seem to be controlled by only a subset of cells implying a systemic regulation in a cell non-autonomous manner. The understanding of the nature of this stress communication across tissues, its mechanisms and impact, will be paramount in understanding disease etiology and the development of therapeutic strategies.