Prognostic significance of standardized uptake value and metabolic tumour volume on 18F-FDG PET/CT in oropharyngeal squamous cell carcinoma
Prognostic significance of standardized uptake value and metabolic tumour volume on 18F-FDG PET/CT in oropharyngeal squamous cell carcinoma
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DOI：
10.1007/s00259-015-3051-4
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发表时间：
2015-08-01
影响因子：
9.1
通讯作者：
Kim, Sang Yoon
中科院分区：
文献类型：
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作者：
Kim, Ji Won;Oh, Jungsu S.;Kim, Sang Yoon
目的：18-氟脱氧葡萄糖（FDG）PET/CT测量的标准化摄取值（SUV）和代谢肿瘤体积（MTV）是新出现的实体癌预后生物标志物。然而，它们在口咽鳞状细胞癌（OPSCC）中的预后意义仅在少数研究和小队列中进行了研究。在本研究中，我们评估的能力SUV，MTV，和总病变糖酵解（TLG）测量预处理F-18-FDG PET/CT预测复发和生存结局OPSCC.Methods该研究包括221例OPSCC谁接受预处理F-18-FDG PET/CT成像和接受明确的治疗在我们的三级转诊中心。在具有局灶性F-18-FDG摄取的原发性肿瘤中测量PET成像参数SUVmax、SUVpeak、MTV和TLG。临床和影像学变量显着相关的总生存期（OS）和无病生存期（DFS）的单变量和多变量分析使用的考克斯比例风险model.Results的总体5年OS和DFS率分别为72.0%和79.5%，分别在中位随访61个月（范围18 - 122个月）。肿瘤SUVmax、SUVpeak、MTV和TLG预测DFS的截断值分别为7.55、6.80、11.06 mL和78.56 g。单因素分析显示，年龄> 60岁、肿瘤分期较晚、肿瘤SUVmax、SUVpeak、MTV和TLG较高与OS和DFS降低显著相关（均P < 0.05）。结论术前F18-FDGPET/CT测量的SUVmax和MTV对预测OPSCC患者的临床预后有一定的价值。
Purpose Standardized uptake value (SUV) and metabolic tumour volume (MTV) measured by F-18-FDG PET/CT are emerging prognostic biomarkers in human solid cancers. However, their prognostic significance in oropharyngeal squamous cell carcinoma (OPSCC) has been investigated in only a few studies and with small cohorts. In the present study we evaluated the ability of SUV, MTV, and total lesion glycolysis (TLG) measured on pretreatment F-18-FDG PET/CT to predict recurrence and survival outcomes in OPSCC.Methods The study included 221 patients with OPSCC who underwent pretreatment F-18-FDG PET/CT imaging and received definitive treatment at our tertiary referral centre. The PET imaging parameters SUVmax, SUVpeak, MTV and TLG were measured in primary tumours with focal F-18-FDG uptake. Clinical and imaging variables significantly associated with overall survival (OS) and disease-free survival (DFS) were identified by univariate and multivariate analyses using the Cox proportional hazards model.Results Overall 5-year OS and DFS rates were 72.0 % and 79.5 %, respectively, during a median follow-up of 61 months (range 18 - 122 months). The cut-off values of tumour SUVmax, SUVpeak, MTV and TLG for prediction of DFS were 7.55, 6.80, 11.06 mL and 78.56 g, respectively. Univariate analyses showed that age > 60 years, advanced tumour stage, and high tumour SUVmax, SUVpeak, MTV and TLG were significantly associated with decreased OS and DFS (P < 0.05 each). Age, tumour SUVmax and MTV remained independent variables for OS and DFS (P < 0.05 each) in the multivariate analyses.Conclusion SUVmax and MTV measured on pretreatment F-18-FDG PET/CT may be useful in predicting the clinical outcomes in OPSCC patients.