Short-term simvastatin treatment has no effect on plasma cytokine response in a human in vivo model of low-grade inflammation
Short-term simvastatin treatment has no effect on plasma cytokine response in a human in vivo model of low-grade inflammation
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DOI：
10.1111/j.1365-2249.2006.03042.x
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发表时间：
2006-04-01
影响因子：
4.6
通讯作者：
Pedersen, BK
中科院分区：
文献类型：
--
作者：
Erikstrup, C;Ullum, H;Pedersen, BK
他汀类药物可以降低血浆胆固醇，但临床试验和体外研究表明，他汀类药物可能还具有抗炎特性。辛伐他汀对循环细胞因子和白细胞的影响在人类体内低级别炎症模型中进行了评估。30名年轻健康男性参与者接受了细菌细胞壁产物内毒素（0.06 ng/kg）的注射，以诱导全身炎症。然后将参与者随机分为对照组和辛伐他汀组。辛伐他汀组每日服用辛伐他汀20mg，连续14天。所有参与者在14天后返回接受第二次内毒素注射。采用酶联免疫吸附试验（ELISA）测定内毒素给药前和给药后6小时血浆中肿瘤坏死因子(TNF)- α、白细胞介素(IL)-6和IL-1受体拮抗剂的浓度。血浆细胞因子和总白细胞计数在内毒素刺激下增加，但辛伐他汀治疗不受影响。14 d后观察两组对内毒素的耐受性。在这项人体体内研究中，辛伐他汀短期治疗（20mg /天）不影响内毒素血症期间循环细胞因子水平。
Statins reduce plasma cholesterol, but clinical trials and in vitro studies indicate that they might also possess anti-inflammatory properties. The effect of simvastatin on circulating cytokines and leucocytes was evaluated in a human in vivo model of low-grade inflammation. Thirty young healthy male participants received an injection of the bacterial cell wall product endotoxin (0.06 ng/kg) to induce systemic inflammation. Participants were then randomized into a control and a simvastatin group. The simvastatin group received simvastatin 20 mg daily for 14 days. All participants returned after 14 days to receive a second endotoxin injection. Plasma concentrations of tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1 receptor antagonist were measured by enzyme-linked immunosorbent assay (ELISA) before and hourly for 6 hours after endotoxin administration. Plasma cytokines as well as total leucocyte counts increased in all participants upon endotoxin challenge but were not affected by simvastatin treatment. Tolerance to endotoxin was observed in both groups after 14 days. Short-term treatment with simvastatin (20 mg/day) did not influence circulating cytokine levels during endotoxaemia in this human in vivo study.