Circadian timing, melatonin and hippocampal volume in later-life adults.
Circadian timing, melatonin and hippocampal volume in later-life adults.
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晚年成年人的昼夜节律、褪黑激素和海马体积。
DOI：
10.1111/jsr.14090
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发表时间：
2023
影响因子：
4.4
通讯作者：
Burgess,HelenJ
中科院分区：
文献类型：
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作者：
Moon,Chooza;Hoth,KarinF;Perkhounkova,Yelena;Zhang,Meina;Lee,Jihye;Hein,Maria;Hopkins,Lauren;Magnotta,Vincent;Burgess,HelenJ
海马区萎缩是阿尔茨海默病和相关痴呆的一个显著的神经退行性改变特征。昼夜节律的改变会加剧认知老化和神经退化。这项研究的目的是研究在认知健康的个体中，昏暗的光线、褪黑素的起始和褪黑素水平如何与海马体体积相关。我们研究了52名晚年成年人的数据(平均年龄 ± ，SD， = ，70.0， ± ，6.3， )。使用BRAINSTools工具箱收集 T磁共振成像数据的T1加权解剖图像并进行处理。用暗淡的褪黑素开始时间来评估昼夜节律。计算曲线下面积以量化睡前6 小时的褪黑素浓度水平，并使用14天的腕部肌动描记数据评估习惯性就寝时间。采用以海马体体积为因变量的多元线性回归模型，对调整年龄和性别的数据进行分析。褪黑素平均起效时间为19：45 h(SD = 84 )，习惯性睡前6 h褪黑素曲线下面积为38.4 pg ml−1× hr(SD = 29.3)。我们发现褪黑素起效时间较晚(b= 0.16，p= 0.005)和习惯性睡前6 小时褪黑素水平曲线下面积较大(b= 0.05，p= 0.046)与较大的调整海马体体积有关。从昏暗的光线褪黑素开始到睡眠时间中点的时间与海马体体积无关。研究结果表明，较早的昼夜节律(暗淡的褪黑素出现)和褪黑素的减少可能与老年人的海马体体积减少有关。未来的研究将帮助研究人员利用昼夜节律信息来延缓大脑衰老。
Hippocampal atrophy is a prominent neurodegenerative feature of Alzheimer's disease and related dementias. Alterations in circadian rhythms can exacerbate cognitive aging and neurodegeneration. This study aimed to examine how dim light melatonin onset and melatonin levels are associated with hippocampal volume in cognitively healthy individuals. We studied data from 52 later‐life adults (mean age ± SD = 70.0 ± 6.3 years). T1‐weighted anatomical images from 3.0 T magnetic resonance imaging data were collected and processed using the BRAINSTools toolbox. Dim light melatonin onset was used to assess circadian timing. The area under the curve was calculated to quantify melatonin concentration levels 6 hr before bedtime, and 14‐day wrist actigraphy data were used to assess habitual bedtime. Multiple linear regression modelling with hippocampal volume as the dependent variable was used to analyse the data adjusting for age and sex. The average dim light melatonin onset was 19:45 hours (SD = 84 min), and area under the curve of melatonin levels 6 hr before habitual bedtime was 38.4 pg ml−1× hr (SD = 29.3). We found that later dim light melatonin onset time (b= 0.16,p= 0.005) and greater area under the curve of melatonin levels 6 hr before habitual bedtime (b= 0.05,p= 0.046) were associated with greater adjusted hippocampal volume. The time between dim light melatonin onset and the midpoint of sleep timing was not associated with hippocampal volume. The findings suggest that earlier circadian timing (dim light melatonin onset) and reduced melatonin may be associated with reduced hippocampal volume in older adults. Future research will help researchers utilize circadian rhythm information to delay brain aging.