Postmortem brain MRI with selective tissue biopsy as an adjunct to autopsy following neonatal encephalopathy
Postmortem brain MRI with selective tissue biopsy as an adjunct to autopsy following neonatal encephalopathy
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DOI：
10.1016/j.ejpn.2006.12.004
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发表时间：
2007-05-01
影响因子：
3.1
通讯作者：
Rutherford, M. A.
中科院分区：
文献类型：
--
作者：
Nicholl, R. M.;Balasubramaniam, V. P.;Rutherford, M. A.
在新生儿死亡后，父母必须获得关于可能死亡原因的完整和准确的信息。围产期尸检经常增加新的信息，甚至可能改变假定的诊断[Cartlidge PH，Dawson AT，Stewart JH，Vujanic GM.围产期和婴儿尸检的价值和质量：400例连续死亡病例的队列分析。Br Med J 1995;310（6973）：155-8; Khong Ty.新生儿尸检率下降。Br Med J 2002;324（7340）：749-50]，告知关于任何未来妊娠的管理的决定。尸检可以被认为是鉴定导致新生儿死亡的前因事件的“金标准”。然而，英国最近的事件增加了新生儿尸检率已经下降[Brodlie M，Laing IA.三级转诊中心新生儿尸检十年：回顾性研究。Br Med J 2002;324（7340）：761-3]。为了试图纠正这种平衡，首席医疗官建议，应委托研究使用非侵入性成像，以提供类似的信息标准[首席医疗官。从死后检查中取出、保留和使用人体器官和组织。伦敦，英格兰：卫生部固定办公室; 2001年]。先前关于死后MRI的出版物主要集中在胎儿和死产的研究[Griffiths PD，Variend D，Evans M，Jones A，威尔金森ID，Paley MNJ，et al. Postmortem MR imaging of the fetal and stillborn central nervous system.美国神经放射学杂志2003;24（1）：22-7;惠特比EH，Paley MN，Cohen M，GriffithsPD.胎儿死后磁共振成像：常规尸检的辅助还是替代？《胎儿和新生儿医学研讨会》2005;10（5）：475-83]。我们报告我们的经验，使用死后脑MRI结合选择性组织活检，在6个新生儿死亡的设置一个大型地区综合医院。(c)2007年由Elsevier Ltd.代表欧洲儿科神经病学学会出版。
Following the death of a neonate It is essential that parents are given full and accurate Received information about the probable cause of death. Perinatal autopsy often adds new information or may even change the presumed diagnosis [Cartlidge PH, Dawson AT, Stewart JH, Vujanic GM. Value and quality of perinatal and infant postmortem examinations: cohort analysis of 400 consecutive deaths. Br Med J 1995;310(6973):155-8; Khong Ty. Falling neonatal autopsy rates. Br Med J 2002;324(7340):749-50] informing decisions regarding the management of any future pregnancy. Autopsy can be considered the "gold standard" for the identification of antecedent events leading to a neonatal death. However, recent events in the UK have added to an already declining rate in neonatal autopsies [Brodlie M, Laing IA. Ten years of neonatal autopsies in tertiary referral centre: retrospective study. Br Med J 2002;324(7340):761-3]. To try and redress this balance the Chief Medical Officer has recommended that research should be commissioned into the use of non-invasive imaging to provide a similar standard of information [The Chief Medical Officer. The removal, retention and use of human organs and tissues from post mortern examination. London, England: The Stationary Office, Department of Health; 2001]. Previous publications on postmortem MRI have focused largely on investigation of the foetus and of still birth [Griffiths PD, Variend D, Evans M, Jones A, Wilkinson ID, Paley MNJ, et al. Postmortem MR imaging of the fetal and stillborn central nervous system. Am J Neuroradiol 2003;24(1):22-7; Whitby EH, Paley MN, Cohen M, GriffithsPD. Postmortem MR imaging of the fetus: an adjunct or a replacement for conventional autopsy? Semin Fetal Neonatal Med 2005;10(5):475-83]. We report our experience on the use of postmortem brain MRI combined with selective tissue biopsy, in six neonatal deaths in the setting of a large district general hospital. (c) 2007 Published by Elsevier Ltd. on behalf of European Paediatric Neurology Society.