The effect of drug abuse on body mass index in Hispanics with and without HIV infection
The effect of drug abuse on body mass index in Hispanics with and without HIV infection
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DOI：
10.1079/phn2004667
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发表时间：
2005-02-01
影响因子：
3.2
通讯作者：
Gorbach, SL
中科院分区：
文献类型：
--
作者：
Forrester, JE;Tucker, KL;Gorbach, SL
目的：人们普遍认为药物滥用者体重减轻与饮食有关。然而，许多关于药物滥用者饮食摄入的研究未能发现能量不足，而非饮食因素很少被研究。本研究的目的是检查非饮食因素可能影响药物滥用者的体重，无论是否感染艾滋病毒。设计：参与者被招募到三组中的一组：hiv阳性药物滥用者（n=85）， hiv阴性药物滥用者（n=102）和hiv阳性但不使用药物的人（“非药物滥用者”，n=98）。影响体重的非饮食因素包括感染艾滋病毒和/或肝炎、吸收不良、静息能量消耗和体力活动。背景：在美国波士顿进行的一项药物滥用在艾滋病毒/艾滋病减肥中的作用的前瞻性队列研究的基线数据。对象：第一批286名参加研究的参与者。结果：hiv阳性药物滥用者的身体质量指数（BMI）明显低于hiv阳性非药物滥用者。体重的差异主要是脂肪的差异。在男性中，可卡因滥用，无论是单独使用还是与阿片类药物混合使用，都与较低的体重指数有关，而严格的阿片类药物滥用则无关。HIV或肝炎感染，肠道吸收不良，静息能量消耗和体力活动，在这项研究中测量，并不能解释观察到的体重和BMI的差异。结论：药物滥用，尤其是可卡因滥用，与男性体重降低有关。然而，感染艾滋病毒和/或肝炎，吸收不良和静息能量消耗不能解释这些发现。
Objective: There is a widely held view that the lower weight of drug abusers is attributable to diet. However, many studies on the dietary intake of drug abusers have failed to find energy insufficiency, while non-dietary factors have rarely been examined. The purpose of this study was to examine non-dietary factors that could affect the weight of drug abusers with and without HIV infection.Design: Participants were recruited into one of three groups: HIV-positive drug abusers (n=85), HIV-negative drug abusers (n=102) and HIV-positive persons who do not use drugs ('non-drug abusers', n=98). Non-dietary factors influencing weight included infection with HIV and/or hepatitis, malabsorption, resting energy expenditure and physical activity.Setting: The baseline data from a prospective cohort study of the role of drug abuse in HIV/AIDS weight loss conducted in Boston, USA.Subjects: The first 286 participants to enrol in the study.Results: HIV-positive drug abusers had a body mass index (BMI) that was significantly lower than that of HIV-positive non-drug abusers. The differences in weight were principally differences in fat. In the men, cocaine abuse, either alone or mixed with opiates, was associated with lower BMI, while strict opiate abuse was not. Infection with HIV or hepatitis, intestinal malabsorption, resting energy expenditure and physical activity, as measured in this study, did not explain the observed differences in weight and BMI.Conclusions: Drug abuse, and especially cocaine abuse, was associated with lower weight in men. However, infection with HIV and/or hepatitis, malabsorption and resting energy expenditure do not explain these findings.