Mindfulness meditation and the immune system: a systematic review of randomized controlled trials.
Mindfulness meditation and the immune system: a systematic review of randomized controlled trials.
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DOI：
10.1111/nyas.12998
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发表时间：
2016-06
影响因子：
5.2
通讯作者：
Slavich GM
中科院分区：
文献类型：
--
作者：
Black DS;Slavich GM
正念冥想代表了一种在日常生活中培养正念意识状态的心理训练框架。最近，人们对正念冥想如何改善人类健康和福祉产生了浓厚的兴趣。尽管研究表明正念冥想可以改善自我报告的疾病症状测量，但正念冥想对人类衰老和疾病的生物学机制的影响尚不清楚。为了解决这个问题，我们对随机对照试验进行了首次全面综述，研究正念冥想对免疫系统参数的影响，特别关注五个结果：(1)循环和刺激的炎症蛋白，(2)细胞转录因子和基因表达，(3)免疫细胞计数，(4)免疫细胞衰老，(5)抗体反应。该分析揭示了各研究在患者群体、研究设计和检测程序方面存在显着的异质性。研究结果表明，正念冥想可能对炎症、细胞介导的免疫和生物衰老的特定标志物产生影响，但这些结果是暂时的，需要进一步复制。在此分析的基础上，我们描述了现有工作的局限性，并提出了未来研究的可能途径。正念调解可能对免疫系统的动态有益，但需要额外的工作来检查这些影响。
Mindfulness meditation represents a mental training framework for cultivating the state of mindful awareness in daily life. Recently, there has been a surge of interest in how mindfulness meditation improves human health and well-being. Although studies have shown that mindfulness meditation can improve self-reported measures of disease symptomatology, the effect that mindfulness meditation has on biological mechanisms underlying human aging and disease is less clear. To address this issue, we conducted the first comprehensive review of randomized controlled trials examining the effects of mindfulness meditation on immune system parameters, with a specific focus on five outcomes: (1) circulating and stimulated inflammatory proteins, (2) cellular transcription factors and gene expression, (3) immune cell count, (4) immune cell aging, and (5) antibody response. This analysis revealed substantial heterogeneity across studies with respect to patient population, study design, and assay procedures. The findings suggest possible effects of mindfulness meditation on specific markers of inflammation, cell-mediated immunity, and biological aging, but these results are tentative and require further replication. On the basis of this analysis, we describe the limitations of existing work and suggest possible avenues for future research. Mindfulness mediation may be salutogenic for immune system dynamics, but additional work is needed to examine these effects.