Detection of antibodies to total histones and their subfractions in systemic lupus erythematosus patients and their asymptomatic relatives.
Detection of antibodies to total histones and their subfractions in systemic lupus erythematosus patients and their asymptomatic relatives.
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系统性红斑狼疮患者及其无症状亲属的总组蛋白及其亚组分抗体的检测。
DOI：
10.1002/art.1780300207
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发表时间：
1987
影响因子：
--
通讯作者：
Isenberg,DA
中科院分区：
文献类型：
--
作者：
Shoenfeld,Y;Segol,G;Segol,O;Neary,B;Klajman,A;Stollar,BD;Isenberg,DA
通过酶联免疫吸附测定，检测了 75 名系统性红斑狼疮患者、141 名健康亲属（来自 51 名患者的家庭）和 115 名健康对照受试者的血清，检测总组蛋白及其亚组分的 IgG 和 IgM 抗体。与对照组相比，统计显着数量的患者及其亲属具有两种同种型的抗组蛋白抗体。在亲属中，女性（尤其是患者的姐妹）的血清含有最高水平的抗总组蛋白抗体。抗 H2A/H2B 和 H3 抗体在狼疮患者中最为普遍，但许多亲属都有 IgM 抗 H4 抗体。这些发现表明抗组蛋白抗体可以作为系统性红斑狼疮患者的遗传标记。
Sera drawn from 75 patients with systemic lupus erythematosus, 141 healthy relatives (from the families of 51 patients), and 115 healthy control subjects were examined, by enzyme‐linked immunosorbent assay, for IgG and IgM antibodies to total histones and their subfractions. Compared with the controls, statistically significant numbers of patients and their relatives had antihistone antibodies of both isotypes. Among the relatives, the sera from females, notably sisters of the patients, contained the highest levels of anti–total histone antibody. Anti‐H2A/H2B and H3 antibodies were most prevalent among the lupus patients, but many of the relatives had IgM anti‐H4 antibodies. These findings indicate that antihistone antibodies can serve as a genetic marker in patients with systemic lupus erythematosus.