Aurora kinases: Generators of spatial control during mitosis.
Aurora kinases: Generators of spatial control during mitosis.
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DOI：
10.3389/fcell.2023.1139367
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发表时间：
2023
影响因子：
5.5
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中科院分区：
文献类型：
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细胞分裂事件需要监管系统来确保事件以不同的顺序发生。细胞周期时间控制的经典观点认为，细胞通过将事件与细胞周期蛋白依赖性激酶(CDK)活性的变化联系起来来对事件进行排序。然而，从对后期的研究中出现了一种新的范式，即染色单体在中央中期板分离，然后移动到细胞的相反两极。这些研究表明，不同的事件是有顺序的，这取决于每条染色体从中央中期板到细长的纺锤体极点的旅程中的位置。这个系统依赖于后期出现的Aurora B激酶活性的梯度，并作为空间灯塔来控制许多后期/末期事件和细胞质分裂。最近的研究还表明，Aurora A激酶的活性决定了染色体或蛋白质在前中期与纺锤体极的接近程度。总而言之，这些研究认为极光激酶的关键作用是提供空间信息，根据染色体或蛋白质沿有丝分裂纺锤体的位置来控制事件。
Cell division events require regulatory systems to ensure that events happen in a distinct order. The classic view of temporal control of the cell cycle posits that cells order events by linking them to changes in Cyclin Dependent Kinase (CDK) activities. However, a new paradigm is emerging from studies of anaphase where chromatids separate at the central metaphase plate and then move to opposite poles of the cell. These studies suggest that distinct events are ordered depending upon the location of each chromosome along its journey from the central metaphase plate to the elongated spindle poles. This system is dependent upon a gradient of Aurora B kinase activity that emerges during anaphase and acts as a spatial beacon to control numerous anaphase/telophase events and cytokinesis. Recent studies also suggest that Aurora A kinase activity specifies proximity of chromosomes or proteins to spindle poles during prometaphase. Together these studies argue that a key role for Aurora kinases is to provide spatial information that controls events depending upon the location of chromosomes or proteins along the mitotic spindle.